A role for wingless in an early pupal cell death event that contributes to patterning the Drosophila eye
A role for wingless in an early pupal cell death event that contributes to patterning the Drosophila eye
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DOI：
10.1016/j.mod.2004.07.004
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发表时间：
2004-12-01
影响因子：
2.6
通讯作者：
Cagan, R
中科院分区：
文献类型：
--
作者：
Cordero, J;Jassim, O;Cagan, R
程序性细胞死亡(PCD)被广泛应用于各种组织中，以完善发育中的组织和器官的结构。然而，对于在发育中的上皮细胞中，结合信号选择性地移除一些细胞，同时保留必要的邻居的机制，人们知之甚少。研究这个问题的一个流行系统是发育中的果蝇蛹视网膜，在这个系统中，多余的网眼间支持细胞被移除，以完善有图案的网眼阵列。在这篇文章中，我们提供的数据表明，PCD发生在幼虫视网膜内的时间比以前证明的更早。与后来的PCD一样，这种死亡取决于Notch的活动。令人惊讶的是，改变果蝇表皮生长因子受体或RAS途径的活性对这种死亡没有影响。相反，我们的证据表明，无翼信号在刺激这种细胞死亡方面发挥了作用。这些信号共同调节了选择性移除不需要的眼间细胞的中间步骤，这是精确的视网膜模式所必需的。(C)2004爱思唯尔爱尔兰有限公司。保留所有权利。
Programmed cell death (PCD) is utilized in a wide variety of tissues to refine structure in developing tissues and organs. However, little is understood about the mechanisms that, within a developing epithelium, combine signals to selectively remove some cells while sparing essential neighbors. One popular system for studying this question is the developing Drosophila pupal retina, where excess interommatidial support cells are removed to refine the patterned ommatidial array. In this paper, we present data indicating that PCD occurs earlier within the pupal retina than previously demonstrated. As with later PCD, this death is dependent on Notch activity. Surprisingly, altering Drosophila Epidermal Growth Factor Receptor or Ras pathway activity had no effect on this death. Instead, our evidence indicates a role for Wingless signaling to provoke this cell death. Together, these signals regulate an intermediate step in the selective removal of unneeded interommatidial cells that is necessary for a precise retinal pattern. (C) 2004 Elsevier Ireland Ltd. All rights reserved.