A COMPARISON OF FAMILIAL AND SPORADIC ALZHEIMERS-DISEASE
A COMPARISON OF FAMILIAL AND SPORADIC ALZHEIMERS-DISEASE
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DOI：
10.1212/wnl.43.7.1377
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发表时间：
1993-07-01
期刊：
影响因子：
9.9
通讯作者：
WEINBERG, GB
中科院分区：
文献类型：
--
作者：
DUARA, R;LOPEZALBEROLA, RF;WEINBERG, GB
使用一个自由的标准，一个保守的概率为基础的标准，和常染色体显性遗传的标准，我们分类36%，13.5%，和6.4%的311例患者，分别为家族性阿尔茨海默病（FAD）。所有三类FAD的平均发病年龄均超过70岁。FAD和散发性阿尔茨海默病（SAD）病例在临床特征、痴呆危险因素的发生率或MRI或PET特征方面没有差异。我们观察到AD的发病年龄较早与疾病持续时间较长呈正相关。除常染色体显性AD组外，FAD先证者的发病年龄均较早。AD遗传自母亲的频率为父亲的1.7 ~ 3.6倍。仅在SAD患者中，我们发现女性占优势，她们比相同平均年龄的一般人群中的男性/女性比例更容易受到影响。与以前的一些报告相反，FAD患者的语言表现往往比SAD患者受影响小。
Using a liberal criterion, a conservative probability-based criterion, and a criterion for autosomal dominant inheritance, we classified 36%, 13.5%, and 6.4% of 311 patients, respectively, as having familial Alzheimer's disease (FAD). The mean age of onset was over 70 years for all three categories of FAD. FAD and sporadic Alzheimer's disease (SAD) cases did not differ in clinical features, incidence of risk factors for dementia, or MRI or PET features. We observed earlier age of onset of AD to be related positively to longer duration of disease. Except for the autosomal dominant AD group, there was an earlier age of onset in FAD probands. The inheritance of AD from mothers was from 1.7 to 3.6 times more frequent than from fathers. Among SAD patients only, we found a preponderance of women, who were more frequently affected than would be expected from the male/female ratio in the general population of the same average age. Language performance tended to be less affected in FAD than in SAD patients, contrary to some previous reports.