Dopamine efflux in response to ultraviolet radiation in addicted sunbed users
Dopamine efflux in response to ultraviolet radiation in addicted sunbed users
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DOI：
10.1016/j.pscychresns.2016.04.001
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发表时间：
2016-05-30
影响因子：
2.3
通讯作者：
Adinoff, Bryon
中科院分区：
文献类型：
--
作者：
Aubert, Pamela M.;Seibyl, John P.;Adinoff, Bryon
尽管意识到紫外线辐射（UVR）的致癌性，但强迫性晒黑可能代表一种“成瘾”行为。许多成瘾障碍与多巴胺（D2/D3）受体结合和大脑奖赏通路中多巴胺反应性的改变有关。为了确定强迫性晒黑者是否表现出与其他成瘾障碍相似的神经生物学反应，本研究评估了10名晒黑成瘾者和10名不常晒黑者的基底纹状体D2/D3结合和uvr诱导的纹状体多巴胺外排。在一项双盲交叉试验中，在单光子发射计算机断层扫描（SPECT）脑成像期间，分别进行UVR或假UVR。使用i -123-碘苯甲酰胺（I-123-IBZM）非可置换结合电位（BPnd）评估尾状核中基础D2/D3受体密度和uvr诱导的多巴胺外排。基础BPnd在晒黑成瘾者和不常晒黑者之间没有显著差异。虽然UVR和假UVR在两组中都没有引起双侧尾状核BPnd的显著变化，但事后分析显示，在晒黑成瘾者中，左尾状核BPnd显著下降（反映多巴胺外排增加），但在UVR期间，不经常晒黑的人却没有。双侧Delta BPnd仅在晒黑成瘾者中与晒黑严重程度相关。这些初步发现与上瘾的晒黑者对紫外线的神经奖励反应更强一致，支持皮肤-神经连接驱动过度使用日光浴床。(C) 2016由爱思唯尔爱尔兰有限公司出版。
Compulsive tanning despite awareness of ultraviolet radiation (UVR) carcinogenicity may represent an "addictive" behavior. Many addictive disorders are associated with alterations in dopamine (D2/D3) receptor binding and dopamine reactivity in the brain's reward pathway. To determine if compulsive tanners exhibited neurobiologic responses similar to other addictive disorders, this study assessed basal striatal D2/D3 binding and UVR-induced striatal dopamine efflux in ten addicted and ten infrequent tanners. In a double-blind crossover trial, UVR or sham UVR was administered in separate sessions during brain imaging with single photon emission computerized tomography (SPECT). Basal D2/D3 receptor density and UVR-induced dopamine efflux in the caudate were assessed using I-123-iodobenzamide (I-123-IBZM) binding potential non-displaceable (BPnd). Basal BPnd did not significantly differ between addicted and infrequent tanners. Whereas neither UVR nor sham UVR induced significant changes in bilateral caudate BPnd in either group, post-hoc analyses revealed left caudate BPnd significantly decreased (reflecting increased dopamine efflux) in the addicted tanners- but not the infrequent tanners during the UVR session only. Bilateral Delta BPnd correlated with tanning severity only in the addicted tanners. These preliminary findings are consistent with a stronger neural rewarding response to UVR in addicted tanners, supporting a cutaneous-neural connection driving excessive sunbed use. (C) 2016 Published by Elsevier Ireland Ltd.