Pyroptosis: mechanisms and diseases.
Pyroptosis: mechanisms and diseases.
复制标题
焦亡：机制和疾病
DOI：
10.1038/s41392-021-00507-5
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发表时间：
2021-03-29
影响因子：
39.3
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Yu P;Zhang X;Liu N;Tang L;Peng C;Chen X
目前，焦亡因其与先天免疫和疾病的关联而受到越来越多的关注。随着热腐菌家族的发现，热腐菌的研究范围不断扩大。大量证据表明，焦亡可以影响肿瘤的发展。在不同的组织和遗传背景下，焦亡与肿瘤的关系是不同的。本文就焦亡的基本知识、焦亡与肿瘤的关系以及焦亡在肿瘤治疗中的意义作一综述。此外，我们进一步总结了焦亡作为一种潜在的肿瘤治疗策略的可能性，并描述了焦亡引起的放疗和化疗的副作用。总之，焦亡对肿瘤来说是一把双刃剑。合理利用这种双重作用将有助于我们进一步探索肿瘤的形成和发展，并为患者开发基于焦亡的新药提供思路。
Currently, pyroptosis has received more and more attention because of its association with innate immunity and disease. The research scope of pyroptosis has expanded with the discovery of the gasdermin family. A great deal of evidence shows that pyroptosis can affect the development of tumors. The relationship between pyroptosis and tumors is diverse in different tissues and genetic backgrounds. In this review, we provide basic knowledge of pyroptosis, explain the relationship between pyroptosis and tumors, and focus on the significance of pyroptosis in tumor treatment. In addition, we further summarize the possibility of pyroptosis as a potential tumor treatment strategy and describe the side effects of radiotherapy and chemotherapy caused by pyroptosis. In brief, pyroptosis is a double-edged sword for tumors. The rational use of this dual effect will help us further explore the formation and development of tumors, and provide ideas for patients to develop new drugs based on pyroptosis.
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DOI：
10.1073/pnas.1607769113
发表时间：
2016-07-12
影响因子：
11.1
作者：
Aglietti, Robin A.;Estevez, Alberto;Dueber, Erin C.
通讯作者：
Dueber, Erin C.
影响因子：
5.7
作者：
Akino, Kimishige;Toyota, Minoru;Tokino, Takashi
通讯作者：
Tokino, Takashi
影响因子：
24.5
作者：
Bauer, Christian;Duewell, Peter;Schnurr, Max
通讯作者：
Schnurr, Max
DOI：
10.1084/jem.20100050
发表时间：
2010-05-10
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Allen IC;TeKippe EM;Woodford RM;Uronis JM;Holl EK;Rogers AB;Herfarth HH;Jobin C;Ting JP
通讯作者：
Ting JP
影响因子：
6.7
作者：
Bergsbaken T;Cookson BT
通讯作者：
Cookson BT