The descending motorcortical pathway to the laryngeal motoneurons in the squirrel monkey
The descending motorcortical pathway to the laryngeal motoneurons in the squirrel monkey
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DOI：
10.1016/j.brainres.2007.02.020
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发表时间：
2007-05-07
期刊：
影响因子：
2.9
通讯作者：
Ehrenreich, Ludwig
中科院分区：
文献类型：
--
作者：
Juergens, Uwe;Ehrenreich, Ludwig
灵长类动物的运动皮层包含一个区域（“喉区”），当单侧刺激时，该区域产生双侧声带内收。为了确定的途径沿着的皮质喉区施加其控制的喉运动神经元，我们已经阻止了兴奋性神经传递的皮质喉区的每个主要投影领域和测试的引出声带运动从这个地区的松鼠猴。通过注射谷氨酸拮抗剂犬尿烯酸进行阻断。我们发现，注射到延髓尾侧同侧的背侧网状核的刺激部位阻断声带运动双边;注射入侵的主要部分的疑核阻断声带运动只同侧的注射部位;和注射集中在小细胞网状结构接壤的疑核阻断只对侧声带运动。我们由此得出结论，皮质延髓喉控制通路突触在同侧背侧网状核，然后分为一个组件直接运行到同侧疑核和第二个组件交叉到对侧疑核后，突触在同侧围疑网状结构。(c)2007 Elsevier B. V.保留所有权利。
The motor cortex of primates contains an area ("larynx area") which, when stimulated unilaterally, produces bilateral vocal fold adduction. In order to identify the pathway along which the cortical larynx area exerts its control on the laryngeal motoneurons, we have blocked excitatory neurotransmission in each of the main projection fields of the cortical larynx area and tested for the elicitability of vocal fold movements from this area in the squirrel monkey. Blocking was carried out by injection of the glutamate antagonist kynurenic acid. We found that injection into the dorsal reticular nucleus of the caudal medulla ipsilateral to the stimulation site blocked vocal fold movements bilaterally; injections invading major parts of the nucleus ambiguus blocked vocal fold movements exclusively ipsilateral to the injection site; and injections centered on the parvocellular reticular formation bordering the nucleus ambiguus blocked exclusively contralateral vocal fold movements. We conclude from this that the corticobulbar laryngeal control pathway synapses in the ipsilateral dorsal reticular nucleus and then divides into one component running directly to the ipsilateral nucleus ambiguus and a second component crossing to the contralateral nucleus ambiguus after having synapsed in the ipsilateral peri-ambigual reticular formation. (c) 2007 Elsevier B.V. All rights reserved.