ULTRASONIC CHARACTERIZATION OF TISSUE STRUCTURE IN THE INVIVO HUMAN-LIVER AND SPLEEN
ULTRASONIC CHARACTERIZATION OF TISSUE STRUCTURE IN THE INVIVO HUMAN-LIVER AND SPLEEN
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DOI：
10.1109/t-su.1984.31522
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发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
SOMMER, FG
中科院分区：
文献类型：
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作者：
FELLINGHAM, LL;SOMMER, FG
组织定征试图提供关于由超声波束询问的组织的疾病或健康状态的定量信息。肝脏和脾脏的弥漫性疾病过程的一个显著特征是正常组织结构的破坏。胶原组织的浸润改变了组织的组织学特征和声学特性。这些变化的散射元素的分布的变化和估计这种分布从组织返回的超声回波的频谱分析的技术的模型。从正常志愿者和弥漫性肝病患者的肝脏以及从正常志愿者和霍奇金病患者的脾脏反向散射的数字化超声波形的分析中获得的结果表明，从该分析确定的“平均散射体间距”给出了与超声图像不可用的组织学特征相关的有用信息，并且在某些情况下，可以提供正常和异常组织之间的有价值的区分。
Tissue characterization attempts to provide quantitative information about the state of disease or health of tissue interrogated by an ultrasound beam. A notable feature of diffuse disease processes of the liver and spleen is disuption of the normal tissue architecture. Infiitration by collagenous tissue changes both the histologic features and acoustic properties of the tissue. A model is presented for these changes as a change in the distribution of scattering elements and a technique for estimating this distribution from analysis of the frequency spectrum of the ultrasonic echoes returned from tissue is described. Results obtained from analysis of digitized ultrasonic waveforms backscattered from the livers of normal volunteers and patients with diffuse liver disease and from the spleens of normal volunteers and patients with Hodgkin’s disease indicate that the “mean scatterer spacing,” determined from this analysis, gives useful information related to histological features that is not available from the ultrasonic image and, in some cases, can provide a valuable discrimination between normal and abnormal tissue.