Role of long non-coding RNAs in cancer: From subcellular localization to nanoparticle-mediated targeted regulation.
Role of long non-coding RNAs in cancer: From subcellular localization to nanoparticle-mediated targeted regulation.
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长非编码RNA在癌症中的作用：从细胞亚定位到纳米粒子介导的靶向调节。
DOI：
10.1016/j.omtn.2023.07.009
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发表时间：
2023-09-12
期刊：
影响因子：
--
通讯作者：
Xu, Xiaoding
中科院分区：
文献类型：
--
作者：
Wei, Chunfang;Xu, Ya;Shen, Qian;Li, Rong;Xiao, Xiaoyun;Saw, Phei Er;Xu, Xiaoding
长链非编码RNA（lncRNA）是一类长度超过200个核苷酸的RNA转录物，在癌症的发生和发展中起着至关重要的作用。随着高通量测序技术的快速发展，大量lncRNA被鉴定为预测癌症患者预后的新型生物标志物和/或癌症治疗的治疗靶点。近年来，越来越多的证据表明lncRNA的生物学功能和调控机制与其亚细胞定位密切相关。更重要的是，基于lncRNA在调节癌症进展中的重要作用（例如，生长、治疗抗性和转移）和核酸的特异性能力（例如，siRNA、mRNA和DNA）来调节任何靶基因的表达，最近已经做出了很多努力来开发基于纳米颗粒（NP）的核酸递送系统，用于体内调节lncRNA表达和癌症治疗。本文介绍了各种功能性lncRNA在肿瘤中的亚细胞定位和调控机制，并系统总结了近年来NP介导的核酸靶向调控lncRNA表达和有效治疗肿瘤的研究进展。Xu及其同事总结了癌症中各种功能性lncRNA的亚细胞定位和调控机制，以及NP介导的核酸递送用于靶向调控lncRNA表达和有效癌症治疗的最新进展。
Long non-coding RNAs (lncRNAs) are a class of RNA transcripts more than 200 nucleotides in length that play crucial roles in cancer development and progression. With the rapid development of high-throughput sequencing technology, a considerable number of lncRNAs have been identified as novel biomarkers for predicting the prognosis of cancer patients and/or therapeutic targets for cancer therapy. In recent years, increasing evidence has shown that the biological functions and regulatory mechanisms of lncRNAs are closely associated with their subcellular localization. More importantly, based on the important roles of lncRNAs in regulating cancer progression (e.g., growth, therapeutic resistance, and metastasis) and the specific ability of nucleic acids (e.g., siRNA, mRNA, and DNA) to regulate the expression of any target genes, much effort has been exerted recently to develop nanoparticle (NP)-based nucleic acid delivery systems for in vivo regulation of lncRNA expression and cancer therapy. In this review, we introduce the subcellular localization and regulatory mechanisms of various functional lncRNAs in cancer and systemically summarize the recent development of NP-mediated nucleic acid delivery for targeted regulation of lncRNA expression and effective cancer therapy. Xu and colleagues summarize the subcellular localization and regulatory mechanisms of various functional lncRNAs in cancer and the recent development of NP-mediated nucleic acid delivery for targeted regulation of lncRNA expression and effective cancer therapy.
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DOI：
10.1261/rna.053561.115
发表时间：
2016-06
期刊：
RNA (New York, N.Y.)
影响因子：
--
作者：
Carlevaro-Fita J;Rahim A;Guigó R;Vardy LA;Johnson R
通讯作者：
Johnson R
影响因子：
64.8
作者：
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通讯作者：
Gustincich, Stefano
DOI：
10.1038/nrc.2017.99
发表时间：
2018-01
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Anastasiadou E;Jacob LS;Slack FJ
通讯作者：
Slack FJ
影响因子：
7.2
作者：
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通讯作者：
Hebert, Daniel N.
影响因子：
64.8
作者：
BARTOLOMEI, MS;ZEMEL, S;TILGHMAN, SM
通讯作者：
TILGHMAN, SM