Synthesis, characterization and in vitro evaluation of magnetic nanoparticles modified with PCL-PEG-PCL for controlled delivery of 5FU (Retracted article. See vol. 50, pg. 108, 2022)
Synthesis, characterization and in vitro evaluation of magnetic nanoparticles modified with PCL-PEG-PCL for controlled delivery of 5FU (Retracted article. See vol. 50, pg. 108, 2022)
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DOI：
10.1080/21691401.2018.1439839
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发表时间：
2018-01-01
影响因子：
5.8
通讯作者：
Akbarzadeh, Abolfazl
中科院分区：
文献类型：
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作者：
Asadi, Nahideh;Annabi, Nasim;Akbarzadeh, Abolfazl
磁性纳米颗粒具有使其应用于癌症治疗和用于递送药物如5 FU的载体的性质，特别是当它们用生物相容性共聚物修饰时。本研究的目的是用PCL-PEG-PCL共聚物修饰超顺磁性氧化铁纳米粒（SPIONP），然后利用这些纳米粒包封抗癌药物5 FU。以己内酯（PCL）和聚乙二醇（PEG 2000）为原料，采用开环聚合法合成了PCL-PEG-PCL共聚物。采用复乳法（水/油/水）制备了PCL-PEG-PCL共聚物修饰的5 FU包覆Fe 3 O 4磁性纳米粒子。采用FT-IR、XRD、VSM和SEM等技术对磁性聚合物纳米粒子的化学结构和磁性能进行了系统的研究。还测定了负载5 FU的NP的体外释放曲线。结果表明，纳米粒的包封率值为90%。此外，与pH 7.4相比，pH 5.8下5 FU的释放显著更高。因此，这些纳米颗粒具有缓释性，可以应用于癌症治疗。
Magnetic nanoparticles have properties that cause to apply them in cancer therapy and vehicles for the delivery of drugs such as 5FU, especially when they are modified with biocompatible copolymers. The aim of this study is to modify superparamagnetic iron oxide nanoparticles (SPIONPs) with PCL-PEG-PCL copolymers and then utilization of these nanoparticles for encapsulation of anticancer drug 5FU. The ring-opening polymerization (ROP) was used for the synthesis of PCL-PEG-PCL copolymer by epsilon-caprolactone (PCL) and polyethylene glycol (PEG2000). We used the double emulsion method (water/oil/water) to prepare 5FU-encapsulated Fe3O4 magnetic nanoparticles modified with PCL-PEG-PCL copolymer. Chemical structure and magnetic properties of 5FU-loaded magnetic-polymer nanoparticles were investigated systematically by employing FT-IR, XRD, VSM and SEM techniques. In vitro release profile of 5FU-loaded NPs was also determined. The results showed that the encapsulation efficiency value for nanoparticles were 90%. Moreover, the release of 5FU is significantly higher at pH 5.8 compared to pH 7.4. Therefore, these nanoparticles have sustained release and can apply for cancer therapy.