Cross-cultural gene- environment interactions in depression, post-traumatic stress disorder, and the cortisol awakening response: FKBP5 polymorphisms and childhood trauma in South Asia.
Cross-cultural gene- environment interactions in depression, post-traumatic stress disorder, and the cortisol awakening response: FKBP5 polymorphisms and childhood trauma in South Asia.
复制标题
DOI：
10.3109/09540261.2015.1020052
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Binder EB
中科院分区：
文献类型：
--
作者：
Kohrt BA;Worthman CM;Ressler KJ;Mercer KB;Upadhaya N;Koirala S;Nepal MK;Sharma VD;Binder EB
尽管对全球心理健康的关注越来越多，但精神病学基因研究一直被高收入国家的研究所主导，特别是欧洲血统的人口。本研究的目的是评估FKBP5基因在南亚人群中的单核苷酸多态(SNPs)。在尼泊尔的成年人中，抑郁症用贝克抑郁量表(BDI)评估，创伤后应激障碍(PTSD)用创伤后应激障碍平民版(PCL-C)评估，童年虐待用儿童创伤问卷(CTQ)评估。对682名受试者进行了FKBP5单核苷酸多态基因分型。对118名参与者进行了为期三天的皮质醇唤醒反应(CAR)评估。FKBP5Tag-SNP rs9296158对抑郁症状有主效作用(p=0.03)。Rs9296158与儿童期虐待的相互作用可预测成人抑郁症状(p=0.02)，但不能预测创伤后应激障碍。儿童期虐待与A等位基因纯合子个体的内分泌反应相关，rs9296158 AA基因型和儿童期虐待组的CAR阴性和总体皮质醇降低证明了这一点(p<；0.001)。这项研究重复了与FKBP5和抑郁症有关的发现，但与创伤后应激障碍无关。按环境进行的基因研究在解释跨文化发现时，应考虑到表型和暴露的流行率和文化意义的差异。
Despite increased attention to global mental health, psychiatric genetic research has been dominated by studies in high-income countries, especially with populations of European descent. The objective of this study was to assess single nucleotide polymorphisms (SNPs) in the FKBP5 gene in a population living in South Asia. Among adults in Nepal, depression was assessed with the Beck Depression Inventory (BDI), posttraumatic stress disorder (PTSD) with the PTSD Checklist-Civilian Version (PCL-C), and childhood maltreatment with the Childhood Trauma Questionnaire (CTQ). FKBP5 SNPs were genotyped for 682 participants. Cortisol awakening response (CAR) was assessed in a subsample of 118 participants over three days. The FKBP5 tag-SNP rs9296158 showed a main effect on depressive symptoms (p=0.03). Interaction of rs9296158 and childhood maltreatment predicted adult depressive symptoms (p=0.02) but not PTSD. Childhood maltreatment associated with endocrine response in individuals homozygous for the A allele, demonstrated by a negative CAR and overall hypocortisolemia in the rs9296158 AA genotype and childhood maltreatment group (p<0.001). This study replicated findings related to FKBP5 and depression but not PTSD. Gene by environment studies should take differences in prevalence and cultural significance of phenotypes and exposures into account when interpreting cross-cultural findings.