Single-Atom Switching as a General Approach to Designing Colorimetric and Fluorogenic Probes for Mercury Ions.
Single-Atom Switching as a General Approach to Designing Colorimetric and Fluorogenic Probes for Mercury Ions.
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DOI：
10.1016/j.dyepig.2020.109014
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发表时间：
2020-11
期刊：
影响因子：
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通讯作者：
A. Loredo;Lushun Wang;Shichao Wang;Han Xiao
中科院分区：
文献类型：
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作者：
A. Loredo;Lushun Wang;Shichao Wang;Han Xiao
通过在常见的荧光团内进行单原子置换，我们已经开发出一种简便和通用的策略来制备用于选择性检测水环境中的汞离子的广谱类比色和荧光探针。现有荧光团核心的羰基的硫化导致荧光的极大降低。在汞离子的存在下，所得到的thiocaged探针被有效地脱硫到它们的氧代衍生物，导致显色和荧光信号的显着变化。由于这些探针表现出高选择性，优异的灵敏度，良好的膜渗透性，并对汞离子的快速响应，它们适合于汞在水和细胞内环境中的可视化。
By performing a single-atom replacement within common fluorophores, we have developed a facile and general strategy to prepare a broad-spectrum class of colorimetric and fluorogenic probes for the selective detection of mercury ions in aqueous environments. Thionation of carbonyl groups from existing fluorophore cores results in a great reduction of fluorescence. In the presence of mercury ions, the resulting thiocaged probes are efficiently desulfurized to their oxo derivatives, leading to pronounced changes in chromogenic and fluorogenic signals. Because these probes exhibit high selectivity, excellent sensitivity, good membrane-permeability, and rapid responses towards mercury ions, they are suitable for visualization of mercury in both aqueous and intracellular environments.