Effect of albumin measurement methods on the albumin?bilirubin grade
Effect of albumin measurement methods on the albumin?bilirubin grade
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白蛋白测量方法对白蛋白、胆红素等级的影响
DOI：
10.1177/00045632221143685
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Takahashi Satoshi
中科院分区：
文献类型：
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作者：
Tanaka Makito;Tanaka Shingo;Suzuki Ema;Kobayashi Ryo;Takahashi Satoshi
背景白蛋白-胆红素（ALBI）等级是基于总胆红素（T-BIL）和白蛋白水平的肝功能指标，其有用性已被广泛报道。本研究旨在探讨不同的方法测量T-BIL和白蛋白水平对ALBI分级的影响在肝脏疾病patients.MethodsIn总数，170例患者从我院被纳入本研究。用钒酸氧化法和酶法测定T-BIL水平之间的相关性进行了分析。同样，对溴甲酚绿色（BCG）和改良溴甲酚紫（BCP）方法之间的白蛋白水平进行相关性分析。此外，ALBI等级计算为肝病患者，和白蛋白测量的每种方法之间的差异进行了compared.ResultsNo差异，观察两种方法之间的T-BIL值的测量。相比之下，100例随机样本和70例肝病患者的白蛋白水平使用改良BCP方法获得的显着低于使用BCG方法测量。BCG法与BCP法的ALBI分级变化率为25.7%。结论白蛋白测定方法对ALBI分级有影响，与其他方法比较时应谨慎。白蛋白测量的标准化是世界范围内需要的。
BackgroundAlbumin–bilirubin (ALBI) grade is an index of liver function based on total bilirubin (T-BIL) and albumin levels, and its usefulness has been widely reported. This study aimed to investigate the effect of different methods of measuring T-BIL and albumin levels on the ALBI grade in patients with liver disease.MethodsIn total, 170 patients from our hospital were included in this study. Correlations between T-BIL levels measured using the vanadate oxidation and enzymatic methods were analysed. Similarly, a correlation analysis of albumin levels between the bromocresol green (BCG) and modified bromocresol purple (BCP) methods was performed. Additionally, the ALBI grade was calculated for patients with liver disease, and the differences between each method of albumin measurement were compared.ResultsNo differences were observed in the measured T-BIL values between the two methods. Contrastingly, the albumin levels of 100 random samples and 70 liver disease patients obtained using the modified BCP method were significantly lower than those measured using the BCG method. The rate of change in the modified ALBI grade between the BCG and BCP methods was 25.7%.ConclusionsCaution should be taken when comparing ALBI grades with those measured by other facilities because the method of albumin measurement can affect the ALBI grade. Standardization of albumin measurement is needed worldwide.