Phosphorus as an early predictive factor in patients with acute liver failure.
Phosphorus as an early predictive factor in patients with acute liver failure.
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DOI：
10.1097/01.tp.0000063219.21313.32
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发表时间：
2003-06-27
期刊：
影响因子：
6.2
通讯作者：
Busuttil, RW
中科院分区：
文献类型：
--
作者：
Baquerizo, A;Anselmo, D;Busuttil, RW
背景本研究旨在分析血清磷在急性肝衰竭（ALF）患者预后中的意义。我们对112例ALF患者进行了回顾性分析。基于Kaplan-Meier恢复曲线和多变量分类树结构生存分析进行单变量和双变量分析，以确定结局的独立预测因素。分析的变量包括年龄、性别、种族、ABO血型、肝病病因、脑病分级、血清胆红素、凝血酶原时间、肌酐、血清磷、所用磷、磷结合剂和血液透析。中位随访时间为5天，中位年龄为28岁，62%的患者为女性。患者的结局如下：28%康复，52%需要原位肝移植，20%死亡。白色患者的预后最好（58%在第一周内恢复），西班牙裔患者的预后最差（0.3%在1周内恢复）（P=0.0001）。脑病和胆红素是恢复的显著预测因素（P
Background. This study analyzes the prognostic significance of serum phosphorus in patients with acute liver failure (ALF).Methods. We performed a retrospective analysis of 112 patients with ALF. Univariate and bivariate analyses based on Kaplan-Meier recovery curves and a multivariate Classification Tree Structure Survival Analysis were performed to identify independent predictors of outcome. The variables analyzed were age, gender, race, ABO blood group, etiology of liver disease, grade of encephalopathy, serum bilirubin, prothrombin time, creatinine, serum phosphorus, phosphorus administered, phosphorus binders, and hemodialysis.Results. The median follow-up time was 5 days, the median age was 28 years, and 62% of the patients were female. The patients' outcomes were as follows: 28% recovered, 52% required orthotopic liver transplantation, and 20% died. White patients showed the best prognosis (58% recovered in the first week), and Hispanics showed the worst prognosis (0.3% recovered at 1 week) (P=0.0001). Encephalopathy and bilirubin were significant predictors of recovery (P