Tick saliva reduces adherence and area of human neutrophils
Tick saliva reduces adherence and area of human neutrophils
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DOI：
10.1128/iai.72.5.2989-2994.2004
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发表时间：
2004-05-01
影响因子：
3.1
通讯作者：
Malawista, SE
中科院分区：
文献类型：
--
作者：
Montgomery, RR;Lusitani, D;Malawista, SE
在莱姆病病原体伯氏疏螺旋体的自然感染过程中，螺旋体与载体唾液一起传递，唾液含有抗炎和止血活性。我们在这里表明，粘蜱的唾液通过下调β -整合素来减少多形核白细胞（PMN）的粘附，并降低PMN吸收和杀死螺旋体的效率。抑制整合素粘附和信号传导可降低PMN的抗炎功能。这些作用可能有利于螺旋体在体内的初始存活。
During natural infection with the agent of Lyme disease, Borrelia burgdorferi, spirochetes are delivered with vector saliva, which contains anti-inflammatory and antihemostatic activities. We show here that the saliva of ixodid ticks reduces polymorphonuclear leukocyte (PMN) adhesion via downregulation of beta2-integrins and decreases the efficiency of PMN in the uptake and killing of spirochetes. Inhibition of integrin adhesion and signaling reduces anti-inflammatory functions of PMN. These effects may favor the initial survival of spirochetes in vivo.