Kinins as mediators of intestinal secretion.
Kinins as mediators of intestinal secretion.
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激肽作为肠道分泌的介质。
DOI：
10.1152/ajpgi.1989.256.1.g1
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Kachur,JF
中科院分区：
文献类型：
--
作者：
Gaginella,TS;Kachur,JF
激肽是一种具有多种生物学作用的小分子肽。纳摩尔或亚纳摩尔范围内的激肽浓度诱导肠平滑肌收缩并引起粘膜电解质分泌。高激肽血症与对胃肠动力和肠粘膜炎症的影响有关。缓激肽和胰激肽是对哺乳动物胃肠道具有作用的主要激肽。缓激肽刺激豚鼠和兔回肠、兔结肠、大鼠结肠和人HCA-7细胞单层的氯离子分泌。激肽直接或间接刺激磷脂酶A2和磷脂酶C。粘膜固有层中的细胞（例如，成纤维细胞、肥大细胞、白细胞）通过释放花生四烯酸的环氧合酶和脂氧合酶代谢物参与激肽反应;然而，不能排除对上皮细胞的直接作用。现在存在激肽受体的拮抗剂。基于在平滑肌制剂中使用这些拮抗剂的研究，已经鉴定了激肽受体的两个亚组。B2型受体似乎负责回肠肌肉的收缩和回肠分泌。激肽作为病理生理介质可能比作为生理介质更重要。它们可能会放大诱导肠道分泌的炎症产物的作用。激肽在临床粘膜分泌状态和腹泻中的精确参与将需要在粘膜炎症的每个阶段对其水平进行定量评估。对激肽作用机制的进一步研究对于设计减轻粘膜炎症相关症状的治疗方案至关重要。
Kinins are small peptides that have diverse biological actions. Concentrations of kinins in the nanomolar or subnanomolar range induce intestinal smooth muscle contraction and evoke mucosal electrolyte secretion. Hyperkininemia is associated with effects on gastrointestinal motility and intestinal mucosal inflammation. Bradykinin and kallidin are the predominant kinins with effects on the gastrointestinal tract of mammals. Bradykinin stimulates chloride ion secretion by the guinea pig and rabbit ileum, rabbit colon, rat colon and monolayers of human HCA-7 cells. Kinins directly or indirectly stimulate phospholipase A2 and phospholipase C. Cells in the lamina propria of the mucosa (e.g., fibroblasts, mast cells, leukocytes), by liberating cyclooxygenase and lipoxygenase metabolites of arachidonic acid, are involved in the kinin response; direct effects on epithelial cells cannot be ruled out, however. Antagonists now exist for kinin receptors. Based on studies with these antagonists in smooth muscle preparations, two subgroups of kinin receptor have been identified. The B2-type receptor appears to be responsible for both the contraction of ileal muscle and ileal secretion. Kinins are probably more important as pathophysiological rather than as physiological mediators. They may amplify the effect of inflammatory products that induce intestinal secretion. The precise involvement of kinins in clinical mucosal secretory states and diarrhea will require quantitative assessment of their levels during each phase of mucosal inflammation. Additional studies on the mechanism of action of kinins will be essential in designing therapy to mitigate the symptoms associated with mucosal inflammation.
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兔肾小管上皮细胞磷脂酶 C 活化与前列腺素 E2 和环磷酸腺苷生成之间的关系。
DOI：
10.1172/jci113376
发表时间：
1988
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Welsh,C;Dubyak,G;Douglas,JG
通讯作者：
Douglas,JG
缓激肽作为疼痛介质：受体定位于感觉神经元，拮抗剂具有镇痛作用。
DOI：
10.1073/pnas.85.9.3245
发表时间：
1988
影响因子：
11.1
作者：
Steranka,LR;Manning,DC;DeHaas,CJ;Ferkany,JW;Borosky,SA;Connor,JR;Vavrek,RJ;Stewart,JM;Snyder,SH
通讯作者：
Snyder,SH
影响因子：
4.8
作者：
K. Anderson;E. Heath
通讯作者：
E. Heath
激肽在大鼠回肠粘膜中的作用位点和机制。
影响因子：
--
作者：
G. Warhurst;M. Lees;N. Higgs;L. Turnberg
通讯作者：
L. Turnberg
Ile-Ser-缓激肽 (T-kinin) 和 Met-Ile-Ser-缓激肽 (Met-T-kinin) 由大鼠肉芽肿组织的酸性蛋白酶从 T-激肽原中释放
影响因子：
3.5
作者：
W. Sakamoto;F. Satoh;K. Gotoh;S. Uehara
通讯作者：
S. Uehara