The endocannabinoid system: 'NO' longer anonymous in the control of nitrergic signalling?
The endocannabinoid system: 'NO' longer anonymous in the control of nitrergic signalling?
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DOI：
10.1093/jmcb/mjx008
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发表时间：
2017-04-01
影响因子：
5.5
通讯作者：
Hundal HS
中科院分区：
文献类型：
--
作者：
Lipina C;Hundal HS
内源性大麻素系统（ECS）是一个关键的细胞信号传导系统，涉及多种细胞功能的调节。重要的是，越来越多的证据表明，ECS的生物学作用可能部分是通过其调节一氧化氮的产生和/或释放的能力来介导的，一氧化氮是一种普遍存在的生物活性分子，其作为一种通用的信号传导中间体发挥作用。在这里，我们回顾和讨论有关的证据ECS介导的调节一氧化氮的产生，以及参与活性氮物种在调节ECS诱导的信号转导突出新兴的工作支持氮调节ECS功能。重要的是，概述的研究表明，ECS和氮能信号系统之间的相互作用可以是刺激性和抑制性的，这取决于细胞环境。此外，这样的串扰可以起到维持适当的细胞功能的作用，而任一系统中的异常都可以破坏细胞内稳态并导致与其失调相关的各种病理。因此，未来针对这些信号系统的研究可能会提供新的见解ECS-一氧化氮信号轴在疾病发展中的潜在作用和/或导致确定新的治疗靶点，用于治疗亚硝化应激相关的神经，心血管和代谢疾病。
The endocannabinoid system (ECS) is a key cellular signalling system that has been implicated in the regulation of diverse cellular functions. Importantly, growing evidence suggests that the biological actions of the ECS may, in part, be mediated through its ability to regulate the production and/or release of nitric oxide, a ubiquitous bioactive molecule, which functions as a versatile signalling intermediate. Herein, we review and discuss evidence pertaining to ECS-mediated regulation of nitric oxide production, as well as the involvement of reactive nitrogen species in regulating ECS-induced signal transduction by highlighting emerging work supporting nitrergic modulation of ECS function. Importantly, the studies outlined reveal that interactions between the ECS and nitrergic signalling systems can be both stimulatory and inhibitory in nature, depending on cellular context. Moreover, such crosstalk may act to maintain proper cell function, whereas abnormalities in either system can undermine cellular homoeostasis and contribute to various pathologies associated with their dysregulation. Consequently, future studies targeting these signalling systems may provide new insights into the potential role of the ECS–nitric oxide signalling axis in disease development and/or lead to the identification of novel therapeutic targets for the treatment of nitrosative stress-related neurological, cardiovascular, and metabolic disorders.