T1, T2, and Fat Fraction Cardiac MR Fingerprinting: Preliminary Clinical Evaluation
T1, T2, and Fat Fraction Cardiac MR Fingerprinting: Preliminary Clinical Evaluation
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DOI：
10.1002/jmri.27415
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发表时间：
2020-10-29
影响因子：
4.4
通讯作者：
Prieto, Claudia
中科院分区：
文献类型：
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作者：
Jaubert, Olivier;Cruz, Gastao;Prieto, Claudia
背景资料：最近引入了狄克逊心脏磁共振指纹（MRF），以同时提供水T-1、水T-2和脂肪分数（FF）图。目的：评估健康受试者中的狄克逊心脏MRF重复性及其在心血管疾病患者队列中的临床可行性。人群：T1 MES体模、水脂体模、11名健康受试者和19名疑似心血管疾病患者。研究类型：前瞻性。场强/序列：1.5T，反转恢复自旋回波（IRSE），多回波自旋回波（MESE），改良Look-Round反转恢复（MOLLI），T-2梯度自旋回波（T-2-GRASE）、6-回波梯度反绕回波（GRE）和狄克逊心脏MRF。评估：在体模和11名健康受试者中，通过对传统MOLLI、T-2-GRASE和PDFF进行重复扫描，评估了狄克逊心脏MRF精度。与常规序列相比，在19例患者中评估了狄克逊心脏MRF天然T-1、T-2、FF、造影后T-1和合成细胞外容积（ECV）图。在患者的间隔和晚期钆增强（LGE）区域进行测量，并使用平均值分布、相关性和Bland-Altman图进行评估。图像质量和诊断信心由三位专家使用5点评分量表进行评估。统计学检验：采用配对Wilcoxon秩和检验和配对t检验。结果：狄克逊心脏MRF在体模和体内均具有良好的精度。间隔平均重复性与T-1的23 msec相似，与T-2的2.2 msec相似，与FF的1%相似。与MOLLI和T-2-GRASE相比，健康受试者/患者的偏倚测量值分别为+37 msec*/+60 msec* 和-8.8 msec*/-8 msec*。在postcontrast T-1（P = 0.17）和合成ECV（P = 0.19）测量无统计学显著差异观察patients.Data结论狄克逊心脏MRF达到良好的整体精度在幻影和健康受试者，同时提供coregistered T-1，T-2，和脂肪分数地图在一个单一的屏气扫描与类似或更好的图像质量比传统的方法在患者。
Background: Dixon cardiac magnetic resonance fingerprinting (MRF) has been recently introduced to simultaneously provide water T-1, water T-2, and fat fraction (FF) maps.Purpose: To assess Dixon cardiac MRF repeatability in healthy subjects and its clinical feasibility in a cohort of patients with cardiovascular disease.Population: T1MES phantom, water-fat phantom, 11 healthy subjects and 19 patients with suspected cardiovascular disease.Study Type: Prospective.Field Strength/Sequence: 1.5T, inversion recovery spin echo (IRSE), multiecho spin echo (MESE), modified Look-Locker inversion recovery (MOLLI), T-2 gradient spin echo (T-2-GRASE), 6-echo gradient rewound echo (GRE), and Dixon cardiac MRF.Assessment: Dixon cardiac MRF precision was assessed through repeated scans against conventional MOLLI, T-2-GRASE, and PDFF in phantom and 11 healthy subjects. Dixon cardiac MRF native T-1, T-2, FF, postcontrast T-1 and synthetic extracellular volume (ECV) maps were assessed in 19 patients in comparison to conventional sequences. Measurements in patients were performed in the septum and in late gadolinium enhanced (LGE) areas and assessed using mean value distributions, correlation, and Bland-Altman plots. Image quality and diagnostic confidence were assessed by three experts using 5-point scoring scales.Statistical Tests: Paired Wilcoxon rank signed test and paired t-tests were applied. Statistical significance was indicated by *(P < 0.05).Results: Dixon cardiac MRF showed good overall precision in phantom and in vivo. Septal average repeatability was similar to 23 msec for T-1, similar to 2.2 msec for T-2, and similar to 1% for FF. Biases in healthy subjects/patients were measured at +37 msec*/+60 msec* and -8.8 msec*/-8 msec* when compared to MOLLI and T-2-GRASE, respectively. No statistically significant differences in postcontrast T-1 (P = 0.17) and synthetic ECV (P = 0.19) measurements were observed in patients.Data Conclusion Dixon cardiac MRF attained good overall precision in phantom and healthy subjects, while providing coregistered T-1, T-2, and fat fraction maps in a single breath-hold scan with similar or better image quality than conventional methods in patients.