Palladium-catalyzed cyanation of aryl bromides promoted by low-level organotin compounds.
Palladium-catalyzed cyanation of aryl bromides promoted by low-level organotin compounds.
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DOI：
10.1021/ol049621d
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发表时间：
2004-07
期刊：
影响因子：
5.2
通讯作者：
Chun-hua Yang;J. Michael Williams
中科院分区：
文献类型：
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作者：
Chun-hua Yang;J. Michael Williams
介绍了一种用低浓度三丁基氯化锡或氰化物催化钯催化芳基溴氰化反应的新方法。该方法催化剂负荷低，反应条件温和。氰化物的来源是KCN。在芳基溴、碘化物和三氟酸盐的氰化反应中，只需要微量的三正丁基锡化合物就能实现高转化率和产率。
A novel method for palladium-catalyzed cyanation of aryl bromides promoted by low-level tri-n-butyltin chloride or cyanide is described. The method features low catalyst loading and mild reaction conditions. KCN is used as the cyanide source. Only trace levels of the tri-n-butyltin compound are required to achieve high conversion and yield in the cyanation of aryl bromides, iodides, and triflates.