Lack of donor-specific tolerance in mice with established anti-Ia-treated islet allografts.
Lack of donor-specific tolerance in mice with established anti-Ia-treated islet allografts.
复制标题
已建立抗 Ia 处理的同种异体胰岛移植物的小鼠缺乏供体特异性耐受性。
DOI：
10.1097/00007890-198336060-00021
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发表时间：
1983
期刊：
影响因子：
6.2
通讯作者：
Bach,FH
中科院分区：
文献类型：
--
作者：
Morrow,CE;Sutherland,DE;Steffes,MW;Najarian,JS;Bach,FH
在链脲佐菌素诱导的糖尿病受体小鼠中，用单克隆Ia抗体体外预处理的胰岛同种异体移植物移植到肾包膜下，100天后血糖正常，与供体相比仅在H-2 K、H-2 K+ I或H-2 K+ I+ D方面存在差异。具有已建立的胰岛同种异体移植物的小鼠不耐受供体特异性皮肤或胰岛抗原，而是以加速的方式排斥供体皮肤移植物。已建立的抗Ia抗体预处理的胰岛同种异体移植物继续表达靶抗原，并且在用供体皮肤移植物激发后仍然容易发生排斥反应。
: Pancreatic islet allografts pretreated in vitro with monoclonal Ia antibody and transplanted beneath the renal capsule result in normoglycemia beyond 100 days in streptozotocin-induced diabetic recipient mice that differ only at H-2 K, H-2 K+ I, or H-2 K+ I+ D from the donors. Mice with established islet allografts are not tolerant of donor-specific skin or islet antigens, but rather reject donor skin grafts in an accelerated fashion. Established anti-Ia antibody pretreated islet allografts continue to express target antigens and remain susceptible to rejection after challenge with donor skin grafts.