Characterization of the lipoidal derivatives of pregnenolone prepared by incubation of the steroid with adrenal mitochondria.
Characterization of the lipoidal derivatives of pregnenolone prepared by incubation of the steroid with adrenal mitochondria.
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通过类固醇与肾上腺线粒体孵育制备的孕烯醇酮类脂衍生物的表征。
DOI：
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发表时间：
1979
影响因子：
4.8
通讯作者：
S. Lieberman
中科院分区：
文献类型：
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作者：
S. Mellon;L. Ponticorvo;S. Lieberman
利用质谱、放射性同位素、色谱和化学技术，已鉴定出5种3 β-羟基-5-异戊烯-20-酮（异戊烯醇酮）的脂肪酸酯为用牛肾上腺线粒体体外生物合成的类脂衍生物的组分。这五种化合物是：花生四烯酸双烯醇酮、亚油酸双烯醇酮、油酸双烯醇酮、棕榈酸双烯醇酮和硬脂酸双烯醇酮。脂肪酸在这五种酯中的分布不同于先前报道的（Cmelik，S.H.W.，和Ley，H.（1977）Comp.Biochem.Physiol.56B，267-270）这些细胞器的脂肪酸组成。
Using mass spectrometric, radioisotopic, chromatographic and chemical techniques, five fatty acid esters of 3 beta-hydroxy-5-pregnen-20-one (pregnenolone) have been identified as components of the lipoidal derivatives biosynthesized in vitro with bovine adrenal mitochondria. The five compounds are: pregnenolone arachidonate, pregnenolone linoleate, pregnenolone oleate, pregnenolone palmitate, and pregnenolone stearate. The distribution of the fatty acids among these five esters is different from the previously reported (Cmelik, S.H.W., and Ley, H. (1977) Comp. Biochem. Physiol. 56B, 267-270) fatty acid composition of these organelles.