Food Addiction, High-Glycemic-Index Carbohydrates, and Obesity.
Food Addiction, High-Glycemic-Index Carbohydrates, and Obesity.
复制标题
DOI：
10.1373/clinchem.2017.273532
复制
发表时间：
2018-01
影响因子：
9.3
通讯作者：
Lennerz JK
中科院分区：
文献类型：
--
作者：
Lennerz B;Lennerz JK
Treatment success in obesity remains low and recently, food addiction has been delineated as an underlying etiologic factor with therapeutic relevance. Specifically, current treatment focuses on reduced food intake and increase of physical activity whereas interventions for addiction encompass behavioral therapy, abstinence, and environmental interventions such as taxation, restrictions on advertising and regulation of school menus. Here, we reviewed the pertinent literature on food addiction with a specific focus on the role of high glycemic index carbohydrates in triggering addictive symptoms. Three lines of evidence support the concept of food addiction: (1) behavioral responses to certain foods are similar compared to substances of abuse; (2) food intake regulation and addiction rely on similar neurobiological circuits; (3) individuals suffering from obesity or addiction show similar neurochemical- and brain activation patterns. High glycemic index carbohydrates elicit a rapid shift in blood glucose and insulin levels, akin to the pharmacokinetics of addictive substances. Akin to drugs of abuse, glucose and insulin signals in the mesolimbic system to modify dopamine concentration. Sugar elicits addiction-like craving and self-reported problem foods are rich in high glycemic index carbohydrates. These properties make high glycemic index carbohydrates plausible triggers for food addiction. Food addiction is a plausible etiological factor contributing to the heterogeneous condition and phenotype of obesity. In at least a subset of vulnerable individuals, high glycemic index carbohydrates trigger addiction-like neurochemical and behavioral responses.
登录
查看更多内容
影响因子：
2.1
作者：
Gearhardt, Ashley;Roberts, Michael;Ashe, Marice
通讯作者：
Ashe, Marice
影响因子：
2.9
作者：
Corwin, RL;Wojnicki, FHE;Young, MA
通讯作者：
Young, MA
食欲调节肽在成瘾的病理生理学中的作用：对药物疗法的影响。
影响因子：
6
作者：
Engel, Jorgen A.;Jerlhag, Elisabet
通讯作者：
Jerlhag, Elisabet
脂肪/碳水化合物比率但不能能量密度决定零食食物的摄入量并激活大脑奖励区域。
影响因子：
4.6
作者：
Hoch T;Kreitz S;Gaffling S;Pischetsrieder M;Hess A
通讯作者：
Hess A
影响因子：
2.9
作者：
Bocarsly, Miriam E.;Berner, Laura A.;Avena, Nicole M.
通讯作者：
Avena, Nicole M.