Serotonergic Inhibition of Intense Jumping Behavior in Mice Lacking PACAP (Adcyap1−/−)
Serotonergic Inhibition of Intense Jumping Behavior in Mice Lacking PACAP (Adcyap1−/−)
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DOI：
10.1196/annals.1317.079
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发表时间：
2006-07
影响因子：
5.2
通讯作者：
N. Shintani;H. Hashimoto;Kazuhiro Tanaka;N. Kawagishi;Chihiro Kawaguchi;Michiyoshi Hatanaka;Y. Ago;T. Matsuda;A. Baba
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文献类型：
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作者：
N. Shintani;H. Hashimoto;Kazuhiro Tanaka;N. Kawagishi;Chihiro Kawaguchi;Michiyoshi Hatanaka;Y. Ago;T. Matsuda;A. Baba
摘要：小鼠垂体腺苷酸环化酶激活多肽（PACAP）的遗传操作揭示了其参与精神功能。我们先前观察到，缺乏编码神经肽PACAP（Adcyap 1 −/−）的Adcyap 1基因的小鼠在置于开放场地等新环境中时表现出强烈的跳跃行为。在这里，我们表明，与野生型小鼠相比，Adcyap 1 −/−小鼠早在至少6周龄时就表现出跳跃行为，并且选择性5-羟色胺（5-HT）再摄取抑制剂氟西汀以及5-羟色胺前体5-羟色氨酸抑制跳跃行为。我们之前的研究显示，Adcyap 1 −/−小鼠脑中的5-HT代谢产物5-羟基吲哚乙酸（5-HIAA）略有减少。综上所述，这些结果表明，在Adcyap 1 −/−小鼠中观察到的跳跃行为存在发育方面的问题，并且跳跃行为可能涉及到肾上腺素能系统。
Abstract: Genetic manipulation of pituitary adenylate cyclase‐activating polypeptide (PACAP) in mice has uncovered its involvement in psychomotor function. We previously observed that mice lacking the Adcyap1 gene encoding the neuropeptide PACAP (Adcyap1−/−) displayed intense jumping behavior when placed in a novel environment such as an open field. Here, we show that Adcyap1−/− mice manifest jumping behavior as early as at least 6 weeks of age when compared with wild‐type mice and that the selective serotonin (5‐HT) reuptake inhibitor, fluoxetine, as well as the serotonin precursor, 5‐hydroxytryptophan, suppress jumping behavior. Our previous study showed a slight decrease in 5‐HT metabolite, 5‐hydroxyindoleacetic acid (5‐HIAA) in Adcyap1−/− mouse brain. Taken together, these results suggest that there is a developmental aspect to the jumping behavior seen in Adcyap1−/− mice, and that jumping behaviour may involve the serotonergic system.