Proviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas.
Proviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas.
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在一些鼠白血病病毒诱导的淋巴瘤中，原病毒与 c-myc 相邻。
DOI：
10.1073/pnas.81.7.2097
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发表时间：
1984
影响因子：
11.1
通讯作者：
Steffen,D
中科院分区：
文献类型：
--
作者：
Steffen,D
对61例小鼠白血病病毒诱导的淋巴瘤进行了检查，以寻找与已知癌基因相邻的前病毒插入的证据。这些淋巴瘤中有五个被发现有改变邻近c-myc。两个淋巴瘤与改变c-myc序列进行了详细检查。获得的证据表明，在这两个淋巴瘤中的c-myc序列的改变是前病毒整合的结果。这一结果表明，小鼠白血病病毒引起的淋巴瘤可能是细胞癌基因插入突变的结果。
Sixty-one murine leukemia virus-induced lymphomas were examined for evidence of proviral insertions adjacent to known oncogenes. Five of these lymphomas were found to have alterations adjacent to c-myc. Two of the lymphomas with altered c-myc sequences were examined in detail. Evidence was obtained showing that the alterations in the c-myc sequences in these two lymphomas were the result of proviral integrations. This result suggests that lymphomagenesis by murine leukemia viruses can result from insertional mutagenesis of cellular oncogenes.