Jumonji domain-containing protein 1A promotes cell growth and progression via transactivation of c-Myc expression and predicts a poor prognosis in cervical cancer.
Jumonji domain-containing protein 1A promotes cell growth and progression via transactivation of c-Myc expression and predicts a poor prognosis in cervical cancer.
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DOI：
10.18632/oncotarget.13208
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发表时间：
2016-12-20
期刊：
影响因子：
--
通讯作者：
Wang X
中科院分区：
文献类型：
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作者：
Liu J;Zhu M;Xia X;Huang Y;Zhang Q;Wang X
Jumonji结构域蛋白1A（JMJD 1A）在几种癌症的发生和发展中起着关键作用。在这里，我们发现JMJD 1A的表达在宫颈癌细胞和组织中增加，并且抑制JMJD 1A抑制宫颈癌细胞的增殖、迁移和侵袭。JMJD 1A诱导c-Myc的转录，这是宫颈癌生长和进展所必需的。JMJD 1A的表达与淋巴结转移（P=0.031）和FIGO分期（P=0.007）有关。c-Myc水平的升高与肿瘤分化程度（P=0.007）和FIGO分期（P<0.001）相关。JMJD 1A蛋白水平与c-Myc表达相关（P<0.001），两者高表达与预后不良相关。生存分析显示JMJD 1A和c-Myc水平是宫颈癌患者的独立预后因素。这些结果表明JMJD 1A是宫颈癌中有希望的治疗靶点。
Jumonji domain-containing protein 1A (JMJD1A) plays a key role in the development and progression of several cancers. Here, we showed that the expression of JMJD1A is increased in cervical cancer cells and tissues, and that suppression of JMJD1A inhibits proliferation, migration, and invasion of cervical cancer cells. JMJD1A induced transcription of c-Myc, which is essential for cervical cancer growth and progression. Clinical data showed that JMJD1A expression correlated with lymph node metastasis (P=0.031) and FIGO stage (P=0.007). Increased c-Myc levels were associated with tumor differentiation (P=0.007) and FIGO stage (P<0.001). JMJD1A protein levels correlated with c-Myc expression (P<0.001), and high co-expression of the two proteins correlated with a poor prognosis. Survival analysis showed that JMJD1A and c-Myc levels are independent prognostic factors for cervical cancer patients. These results suggest that JMJD1A is a promising therapeutic target in cervical cancer.