Interrelation of Glycemic Status and Neuropsychiatric Disturbances in Farmers with Organophosphorus Pesticide Toxicity.
Interrelation of Glycemic Status and Neuropsychiatric Disturbances in Farmers with Organophosphorus Pesticide Toxicity.
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DOI：
10.2174/1874091x01610010027
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Singh, Sangram
中科院分区：
文献类型：
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作者：
Jamal, Farrukh;Haque, Quazi S;Singh, Sangram
背景：农民不分青红皂白地喷洒各种农用化学品以控制病虫害，以提高作物产量。在发展中国家，约有2500万农业工人每年至少中毒一次，主要是抗胆碱酯酶类有机磷(OP)。目的：本研究旨在从神经认知功能障碍、心理健康状况、临床症状、糖尿病和血液学因素方面确定勒克瑙马利哈巴德芒果种植园187名职业暴露者的OP毒性。方法：将接触组与来自印度勒克瑙马利哈巴德农村从事正常农业工作的187名正常健康人(年龄、性别和受教育程度)进行比较。神经认知障碍的测量使用主观神经认知问卷，心理健康状况使用一般健康问卷-28。受试者还接受了生化和酶参数的检测。结果：接触农民的酶和临床参数发生了变化。而影响精神运动速度、选择性注意、分散注意力、言语记忆、非言语记忆、前瞻记忆、空间功能和主动性/精力的障碍均低于农药喷雾者。农药喷雾者出现湿疹、唾液分泌、乏力、头痛、出汗、腹痛、恶心、上远端肌肉无力、下远端肌肉无力、手刺痛等临床症状，这些症状均与工作年限显著相关。结论：这些发现提示从事农药喷雾者易患神经心理障碍和糖尿病。
BACKGROUND: Diverse group of agro-chemicals are indiscriminately sprayed by the farmers for pest control to enhance crop yield. About 25 million agricultural workers in the developing world suffer from at least one episode of poisoning each year, mainly by anticholinesterase- like organophosphates (OPs).OBJECTIVE: The present study was aimed to establish the OP toxicity in 187 occupationally exposed pesticide sprayers of mango plantation in rural Malihabad, Lucknow, in terms of neuro-cognitive impairment, mental health status, clinical symptoms, diabetes, and hematological factors.METHOD: The exposed group was compared to 187 pesticides-unexposed normal healthy persons engaged in normal usual agricultural work (age, sex and education corresponding to age group of selected subject group) from Rural Malihabad, Lucknow (India). Neuro-cognitive impairment was measured using the Subjective Neurocognition Inventory and mental health status using the General Health questionnaire-28. The subjects were also tested for biochemical and enzymatic parameters.RESULTS: The exposed farmers showed alterations in enzymatic and clinical parameters. While the rates of anxiety / insomnia and severe depression were also significantly higher in the pesticide sprayers, disorders affecting psychomotor speed, selective attention, divided attention, verbal memory, nonverbal memory, prospective memory, spatial functioning, and initiative/energy were all lower in the sprayers. Pesticide sprayers showed a number of clinical symptoms like eczema, saliva secretion, fatigue, headache, sweating, abdominal pain, nausea, superior distal muscle weakness, inferior distal muscle weakness, hand tingling and etc. which all significantly correlated with the number of working years.CONCLUSION: These findings suggested that farmers who work with OPs are prone to neuro-psychological disorders and diabetes.