Strain and Sex Differences in Anxiety-Like and Social Behaviors in C57BL/6J and BALB/cJ Mice
Strain and Sex Differences in Anxiety-Like and Social Behaviors in C57BL/6J and BALB/cJ Mice
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C57BL/6J 和 BALB/cJ 小鼠焦虑样行为和社交行为的应变和性别差异
DOI：
10.1538/expanim.60.111
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发表时间：
2011-04-01
影响因子：
2.4
通讯作者：
Broders, Hugh
中科院分区：
文献类型：
--
作者：
An, Xiao-Lei;Zou, Jun-Xian;Broders, Hugh
情绪障碍在女性中比男性更常见，然而，大多数研究都集中在雄性啮齿动物作为动物模型。我们使用各种常见的行为测试来寻找C57 BL/6 J和BALB/cJ小鼠之间和内部的焦虑样和社会行为的差异。我们的研究结果表明，雌性C57 BL/6 J小鼠表现出较低水平的焦虑样行为和较高水平的活动比雌性BALB/cJ在开放领域和高架十字迷宫测试。主成分分析产生更多的因素，男性的行为变量比女性。在开放领域，也发现了性别差异和因素1出现在男性的焦虑，和运动活动的女性。虽然C57 BL/6 J小鼠被发现具有更高水平的社会探索和社会接触，但在这两种品系中发现了性别差异（女性更具社会性）。在与同性动物交往时，雄性和雌性C57 BL/6 J小鼠的嗅体和蜷缩水平均高于雄性和雌性BALB/cJ小鼠。然而，在性别间的相互作用，雄性C57 BL/6 J小鼠嗅刺激小鼠少，和雌性C57 BL/6 J小鼠嗅刺激更多的BALB/cJ小鼠相比。这项研究提供了重要的行为表型，并证实了两个广泛使用的小鼠品系的多维行为结构。
Mood disorders are more frequent in women than men, however, the majority of research has focused on male rodents as animal models. We used a variety of common behavioral tests to look for differences in anxiety-like and social behaviors between and within C57BL/6J and BALB/cJ mice. Our results show that female C57BL/6J mice exhibited lower levels of anxiety-like behavior and higher levels of activity than female BALB/cJ during the open field and elevated plus maze tests. Principal component analysis generated more factors in the behavioral variables of males than females. In the open field, a sex difference was also found and factor 1 emerged as anxiety in males, and motor activity in females. While C57BL/6J mice were found to have higher levels of social exploration and social contacts, differences were found between the sexes (females were more social) in both strains for this measure and also for anxiety-like behaviors. When interacting with animals of the same sex, levels of sniffing body and huddling in both male and female C57BL/6J mice were higher than those in male and female BALB/cJ mice. However, in the between-sex interactions, male C57BL/6J mice sniffed the stimulus mouse less, and female C57BL/6J mice sniffed the stimulus more compared to BALB/cJ mice. This study provides important behavioral phenotypes and confirms the multidimensional behavioral structure of two widely used mice strains.