DIFFERENTIAL OUTCOME TO MIDDLE CEREBRAL-ARTERY OCCLUSION IN SPONTANEOUSLY HYPERTENSIVE STROKE-PRONE RATS (SHRSP) AND WISTAR KYOTO (WKY) RATS
DIFFERENTIAL OUTCOME TO MIDDLE CEREBRAL-ARTERY OCCLUSION IN SPONTANEOUSLY HYPERTENSIVE STROKE-PRONE RATS (SHRSP) AND WISTAR KYOTO (WKY) RATS
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DOI：
10.1161/01.str.14.4.605
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发表时间：
1983-01-01
期刊：
影响因子：
8.3
通讯作者：
JOKELAINEN, PT
中科院分区：
文献类型：
--
作者：
COYLE, P;JOKELAINEN, PT
研究发现，与假手术对照组和 Wistar 京都大鼠 (WKY) 相比，年轻遗传性高血压脑卒中易感大鼠 (SHRSP) 大脑中动脉闭塞的结果不同。在定性和定量上，以伊文思蓝白蛋白、皮质萎缩、大面积显着改变的皮质组织学、术后生存和运动行为缺陷为标志的不同肉眼病变将年轻的 SHRSP 与假手术对照和正常血压的 WKY 区分开来。在正常血压和假手术大鼠中观察到的有限局灶性病变主要是由于暴露血管并将结扎线深入血管的手术创伤所致。 SHRSP 中较大且性质不同的病变是大脑背动脉侧支循环不足的结果。由于5-6周龄的SHRSP仅患有轻度高血压（收缩压140毫米汞柱），因此侧支循环不足似乎与遗传或后天问题有关，而不是继发于慢性高血压的血管病变。
Evidence was found for different outcomes to middle cerebral artery occlusion in the young genetically hypertensive stroke-prone rat (SHRSP) compared to sham operated controls and the Wistar Kyoto rat (WKY). Qualitatively and quantitatively, different gross lesions marked by Evans blue-albumin, cortical atrophy, large areas of strikingly altered cortical histology, postoperative survival and motor behavioral deficits differentiate young SHRSP from sham operated controls and the normotensive WKY. The limited focal lesion observed in normotensive and sham operated rats is primarily due to surgical trauma of exposing the vessel and passing the ligature deep to it. The grossly larger and qualitatively different lesion in the SHRSP is the result of an inadequate circulation provided by the dorsal cerebral arterial collaterals. Since the 5-6 wk old SHRSP were only mildly hypertensive (systolic blood pressure 140 mm Hg), the inadequate collateral circulation appears to be related to either a genetic or acquired problem, rather than being secondary to a vascular lesion of chronic hypertension.