Intestinal disaccharidase activities in relation to age, race, and mucosal damage.
Intestinal disaccharidase activities in relation to age, race, and mucosal damage.
复制标题
肠道二糖酶活性与年龄、种族和粘膜损伤有关。
DOI：
10.1016/0016-5085(78)90468-7
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发表时间：
1978
期刊：
影响因子：
29.4
通讯作者：
D. E. Stevenson
中科院分区：
文献类型：
--
作者：
J. Welsh;J. Poley;M. Bhatia;D. E. Stevenson
进行了研究，以确定肠二硫键酶活性的关系，年龄和种族，粘膜损伤的关系，一个原发性低乳糖酶活性。第一项研究包括399人（339名白人，53名黑人和7名美洲印第安人）的数据，年龄从1个月到93岁，肠道组织学正常。在白人中，所有117名5岁或5岁以下的儿童都有高乳糖酶水平，而只有5岁以上的受试者才有低水平。在11名3岁或3岁以下的黑人儿童中，没有发现低乳糖酶水平，但与同龄白色儿童相比，他们的平均乳糖酶活性显著降低。在白人和黑人中，α-二磷酸腺苷酶不参与乳糖酶的年龄相关变化。在7名26个月以下的印第安人中，没有一个乳糖酶水平低，而10岁以上的4人乳糖酶水平低。蔗糖酶-异麦芽糖酶缺乏症的杂合子只在白人中发现。在所有研究的种族中，低乳糖酶水平在儿童时期发展，然而，许多人由于未知原因一直保持乳糖耐受性直到成年。在第二项研究中，另外13名儿童继发性二磷酸腺苷酶缺乏症，出现原发性低乳糖酶与年龄和种族，而不是粘膜损伤。在5岁以下的白人和3岁以下的黑人中，原发性低肠道乳糖酶水平似乎是不存在或罕见的，并且这种缺乏与肌肉损伤无关。
Studies were undertaken to determine the relationship of intestinal disaccharidase activity to age and race, and the relationship of mucosal damage to a primary low lactase activity. The first study consisted of data on 399 persons (339 whites, 53 blacks, and 7 American Indians) ages 1 month to 93 years, with normal intestinal histology. Among whites, all 117 children 5 years old or under had high lactase levels, whereas low levels were found only in subjects over 5 years of age. No low lactase levels were identified among the 11 black children 3 years old or under, but in comparison to coetaneous white children, their mean lactase activity was significantly less. The majority of older blacks had low lactases. In whites and blacks α-disaccharidases did not participate in the age-related changes demonstrated with lactase. Of the 7 American Indians, none under 26 months old had low lactase levels, whereas the 4 over 10 years old had low activities. Heterozygotes for sucrase-isomaltase deficiency were identified only among whites. Low lactase levels developed during childhood in all races studied, however, many for unknown reasons maintained their lactose tolerance until adulthood. In the second study of 13 additional children with secondary disaccharidase deficiencies, emergence of a primary low lactase was related to age and race, rather than to mucosal damage. It appears that primary low intestinal lactase levels are absent or rare in whites under 5 and blacks under 3 years of age, and the deficiency is not related to muscosal damage.