IMP3 expression is correlated with histologic grade of lung adenocarcinoma
IMP3 expression is correlated with histologic grade of lung adenocarcinoma
复制标题
DOI：
10.1016/j.humpath.2009.10.004
复制
发表时间：
2010-04-01
期刊：
影响因子：
3.3
通讯作者：
Xu, Haodong
中科院分区：
文献类型：
--
作者：
Findeis-Hosey, Jennifer J.;Yang, Qi;Xu, Haodong
胰岛素样生长因子II mRNA结合蛋白3是一种癌胚蛋白，在多种恶性肿瘤中表达。本研究旨在探讨胰岛素样生长因子Ⅱ mRNA结合蛋白3表达与肺腺癌组织学分级的关系。其中不典型腺瘤样增生11例，单纯细支气管肺泡癌10例，高分化腺癌36例，中低分化腺癌41例。使用抗胰岛素样生长因子II mRNA结合蛋白3的单克隆抗体进行免疫化学研究。41例中分化至低分化腺癌中有29例（70.7%）胰岛素样生长因子II mRNA结合蛋白3阳性，其中26例（89.7%）肿瘤显示强染色或染色超过30%的肿瘤细胞。10例细支气管肺泡癌和36例高分化腺癌中分别有4例（40.0%）和13例（36.1%）表达胰岛素样生长因子Ⅱ mRNA结合蛋白3（IGF 3）。当细支气管肺泡癌以单纯形式存在或作为腺癌的组成部分时，阳性胰岛素样生长因子II mRNA结合蛋白3染色总是斑片状的，少于20%的肿瘤细胞染色。总的来说，与中/低分化腺癌相比，细支气管肺泡癌和高分化腺癌中胰岛素样生长因子II mRNA结合蛋白3染色阳性的频率较低（P <0.01）。在任何非典型腺瘤性增生病例中均未检测到胰岛素样生长因子II mRNA结合蛋白3信号。这些发现表明胰岛素样生长因子II mRNA结合蛋白3在大部分中/低分化肺腺癌中强烈和弥漫性表达，特别是在混合亚型腺癌的实体成分中，在高分化腺癌和细支气管肺泡癌中表达较少，在非典型腺瘤性增生中为阴性。中/低分化腺癌中较高的表达频率表明胰岛素样生长因子II mRNA结合蛋白3表达可能与侵袭性生物学行为相关。(C)2010年爱思唯尔公司All rights reserved.
Insulin-like growth factor II mRNA binding protein 3 is an oncofetal protein that is expressed in multiple malignancies. This study aimed to determine the correlation of insulin-like growth factor II MRNA binding protein 3 expression with histologic grade of lung adenocarcinoma. Eighty-nine cases, including 11 atypical adenomatous hyperplasias, 10 pure bronchioloalveolar carcinomas, 36 well-differentiated adenocarcinomas and 41 moderately or poorly differentiated adenocarcinomas. were immunohistochemically studied using a monoclonal antibody against insulin-like growth factor II mRNA binding protein 3. Twenty-nine (70.7%) of 41 moderately to poorly differentiated adenocarcinomas were positive for insulin-like growth factor II mRNA binding protein 3, with 26 (89.7%) tumors demonstrating either a strong staining or staining in greater than 30% of tumor cells. Four (40.0%) of 10 bronchioloalveolar carcinomas and 13 (36.1%) of 36 well-differentiated adenocarcinomas exhibited insulin-like growth factor II mRNA binding protein 3 positivity with a variable degree and percentage of tumor cells staining. When bronchioloalveolar carcinomas were present in a pure form or as a component of adenocarcinomas, positive insulin-like growth factor II mRNA binding protein 3 staining was always patchy, with less than 20% of tumor cells stained. Overall, the frequency of positive insulin-like growth factor II mRNA binding protein 3 staining was lower in bronchioloalveolar carcinomas and well-differentiated adenocarcinomas compared to moderately/poorly differentiated adenocarcinomas (P < .01). No insulin-like growth factor II mRNA binding protein 3 signal was detected in any case of atypical adenomatous hyperplasia These findings show that insulin-like growth factor II mRNA binding protein 3 is strongly and diffusely expressed in a large proportion of moderately/poorly differentiated lung adenocarcinomas, in particular in the solid component of mixed subtype adenocarcinomas, less frequently expressed in well-differentiated adenocarcinomas and bronchioloalveolar carcinomas, and negative in atypical adenomatous hyperplasias. The higher frequency of expression in moderately/poorly differentiated adenocarcinomas suggests that insulin-like growth factor II mRNA binding protein 3 expression may be associated with an aggressive biological behavior. (C) 2010 Elsevier Inc. All rights reserved.