Acupuncture at homotopic acupoints exerts dual effects on bladder motility in anesthetized rats
Acupuncture at homotopic acupoints exerts dual effects on bladder motility in anesthetized rats
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针刺同位穴对麻醉大鼠膀胱运动具有双重作用
DOI：
10.1186/s12906-015-0781-6
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发表时间：
2015-08-08
影响因子：
--
通讯作者：
Zhu, Bing
中科院分区：
文献类型：
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作者：
Qin, Qingguang;Mo, Qian;Zhu, Bing
在中医中，对靶器官的双重作用被认为是穴位的主要特征。根据脊髓节段神经支配，穴位可分为异位或同位：同位穴位在同一节段包含传入神经支配，传出纤维支配目标内脏器官，异位穴位利用不同的脊髓节段而不是接受传入信号的节段来支配目标内脏器官。众所周知，针刺对膀胱的双重作用可以根据膀胱的不同状态而产生，但单穴位刺激和穴位特异性（同位穴位和异位穴位）对膀胱的双重作用尚未研究。方法麻醉大鼠20只，用测压球囊测膀胱内压力。分别在RN1（回阴）、RN3（中基）、BL28（旁光俞）、BL32（睫廓）、RN2（曲谷）或BL23（肾俞）穴插入针深4mm，并以2 Hz的频率手动从右向左旋转1min。针刺刺激后，记录膀胱压力并与刺激前的测量结果进行比较。结果在膀胱活动状态下，针刺RN1、RN3、BL28、BL32、RN2对膀胱运动均有抑制作用（P< 0.01）。在静态膀胱中，RN1、RN3、BL28、BL32、RN2或BL23的MA均能增加膀胱运动（P< 0.01）。结论sma在同位穴位对膀胱运动可能产生双重作用：在活动状态下抑制膀胱运动，在静止状态下增强膀胱运动。
BackgroundIn Chinese medicine, dual effects on target organs are considered a primary characteristic of acupoint. Acupoints may be classified as heterotopic or homotopic in terms of spinal segmental innervation: homotopic acupoints contain afferent innervation in the same segment from which efferent fibers innervate target visceral organs, and heterotopic acupoints utilize different spinal segments to innervate target visceral organs than the segment receiving the afferent signal. It is well-known that dual effects of acupuncture on the bladder can be generated based on different states of the bladder, however, the dual effects of single acupoint stimulation and acupoint site-specificity (homotopic acupoints and heterotopic acupoints) on the bladder have yet to be investigated.MethodsTwenty Sprague-Dawley rats were anesthetized and the intravesical pressure was measured via a manometric balloon inserted into the bladder. The acupuncture needle was separately inserted to a depth of 4 mm at the acupoints RN1 (Huiyin), RN3 (Zhongji), BL28 (Pangguangshu), BL32 (Ciliao), RN2 (Qugu) or BL23 (Shenshu), and manually rotated right then left with a frequency of 2 Hz for 1 min. Following acupuncture stimulation, bladder pressure was recorded and compared against the pre-stimulation measurements.ResultsDuring the bladder’s active state, manual acupuncture (MA) at RN1, RN3, BL28, BL32 or RN2 inhibited bladder motility (P< 0.01). In the static bladder, MA at RN1, RN3, BL28, BL32, RN2 or BL23 increased bladder motility (P< 0.01).ConclusionsMA at homotopic acupoints may produce dual effects on bladder motility: inhibiting bladder motility when in an active state and enhancing bladder motility when in a static state.