DETECTION OF DYSPLASIA AND CARCINOMA INSITU WITH A LUNG IMAGING FLUORESCENCE ENDOSCOPE DEVICE
DETECTION OF DYSPLASIA AND CARCINOMA INSITU WITH A LUNG IMAGING FLUORESCENCE ENDOSCOPE DEVICE
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DOI：
10.1016/s0022-5223(19)33775-4
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发表时间：
1993-06-01
影响因子：
6
通讯作者：
PALCIC, B
中科院分区：
文献类型：
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作者：
LAM, S;MACAULAY, C;PALCIC, B
使用来自53名患者和41名志愿者的328个活检确认部位的数据库，将新型支气管镜荧光成像系统的性能与传统的白色光学支气管镜检查进行了比较。发现两种方法具有相同的特异性（94%）;然而，发现荧光系统的灵敏度（72.5%）比白色光支气管镜（48.4%）在检测异型增生和原位癌方面高50%。荧光系统使用非线性判别函数，其结合红色和绿色图像强度值以形成伪图像，当在RGB监视器上显示时，该伪图像允许检测和描绘异常区域。在15%的肺癌患者中，除了大浸润癌外，还发现了同步原位癌。在这项研究中，目前吸烟者中，40%有中度异型增生，12%有重度异型增生。对于戒烟者，25%有中度异型增生，6%有重度异型增生，13%有原位癌。荧光成像可能成为传统支气管镜检查的重要辅助手段，以提高我们更准确地诊断和分期肺癌的能力。
The performance of a novel bronchoscopic fluorescence imaging system was compared with conventional white light bronchoscopy with a data base of 328 biopsy-confirmed sites from 53 patients and 41 volunteers. The two methods were found to have the same specificity (94 %); however, the sensitivity of the fluorescence system (72.5%) was found to be 50% greater than that of the white light bronchoscopy (48.4%) in detecting dysplasia and carcinoma in situ. The fluorescence system uses a nonlinear discriminant function combining the red and green image intensity values to form a pseudoimage that, when displayed on an RGB monitor, allows the detection arid delineation of abnormal areas. In 15% of the patients with lung cancer, synchronous carcinoma in situ was found in addition to the large invasive cancer. Of the current smokers in this study, 40% had moderate dysplasia and 12% had severe dysplasia. For the ex-smokers 25% had moderate dysplasia, 6% had severe dysplasia, and 13% had carcinoma in situ. Fluorescence imaging may become an important adjunct to conventional bronchoscopic examination to improve our ability to diagnose and stage lung cancer more accurately.