Synthetic Studies on Glycosphingolipids from Protostomia Phyla: Synthesis of Glycosphingolipids from the Parasite Schistosoma mansoni
Synthetic Studies on Glycosphingolipids from Protostomia Phyla: Synthesis of Glycosphingolipids from the Parasite Schistosoma mansoni
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DOI：
10.1248/cpb.58.811
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发表时间：
2010-06-01
影响因子：
1.7
通讯作者：
Hada, Noriyasu
中科院分区：
文献类型：
--
作者：
Kanaya, Takayuki;Yagi, Satomi;Hada, Noriyasu
已经实现了从寄生虫曼氏血吸虫成虫中合成三种中性糖鞘脂。这些结构与其他寄生虫的结构显着不同，并表现出一种独特的结构基序，称为“片吸核心”，由 GalNAc beta 1 -> 4Glc beta 1 -> 序列组成。我们合成了鞘糖脂，β-D-GalNAcp-(1 -> 4)-beta-D-Glcp-(1 -> 1)Cer (1)、beta-D-GlcNAcp-(1 -> 3)-beta-D-GalNAcp-(1 -> 4)-beta-D-Glcp-(1 -> 1)Cer (2) 和 beta-D-Galp-(1 -> 4)-β-D-GlcNAcp-(1 -> 3)-β-D-GalNAcp-(1 -> 4)-β-D-Glcp-(1 -> 1)Cer (3)。
Synthetic access to three neutral glycosphingolipids from the parasite Schistosoma mansoni adult worm has been achieved. These structures differ significantly from those of other parasites and exhibit a unique structural motif termed "schisto-core" consisting of GalNAc beta 1 -> 4Glc beta 1 -> sequence. We have synthesized glycosphingolipids, beta-D-GalNAcp-(1 -> 4)-beta-D-Glcp-(1 -> 1)Cer (1), beta-D-GlcNAcp-(1 -> 3)-beta-D-GalNAcp-(1 -> 4)-beta-D-Glcp-(1 -> 1)Cer (2) and beta-D-Galp-(1 -> 4)-beta-D-GlcNAcp-(1 -> 3)-beta-D-GalNAcp-(1 -> 4)-beta-D-Glcp-(1 -> 1)Cer (3).