Heterocycle synthesis by palladium catalysed cyclisation-anion capture processes. A powerful new strategy
Heterocycle synthesis by palladium catalysed cyclisation-anion capture processes. A powerful new strategy
复制标题
通过钯催化环化-阴离子捕获过程合成杂环。
DOI：
10.1002/jhet.5570310305
复制
发表时间：
1994
影响因子：
2.4
通讯作者：
R. Grigg
中科院分区：
文献类型：
--
作者：
R. Grigg
钯盐和络合物是构建碳-碳和碳-杂原子键的非常通用的催化剂[1]。由于Heck反应的技术简单性和对多种官能团的耐受性，最近的许多注意力集中在Heck反应[2]上。在过去的十年里，这种钯催化的芳基、杂芳基、乙烯基和苯基卤化物的乙烯基化反应的范围已经大大扩大。我们自己的早期研究[3]证明了分子内Heck反应[4]对于构建桥环[5]、螺环和四取代碳中心[7]具有相当大的通用性。典型的例子由1-#2[6]和3-#4[5]提供。
Palladium salts and complexes are exceptionally versatile catalysts for the construction of carbon-carbon and carbon-heteroatom bonds [1]. Much recent attention has focused on the Heck reaction [2] due to its technical simplicity and tolerance of a wide variety of functional groups. The scope of this palladium catalysed vinylation of aryl, heteroaryl, vinyl and benzyl halides has been substantially extended over the past decade. Our own early researches [3] demonstrated the considerable versatility of the intramolecular Heck reaction [4] for the construction of bridged-rings [5], spirocycles and tetrasubstituted carbon centers [7]. Typical examples are provided by 1—» 2 [6] and 3-» 4 [5].