Fas ligand expression is a risk factor for liver metastasis in colorectal cancer with venous invasion.
Fas ligand expression is a risk factor for liver metastasis in colorectal cancer with venous invasion.
复制标题
Fas配体表达是结直肠癌静脉侵犯肝转移的危险因素。
作者：
H. Yokomizo;K. Yoshimatsu;K. Ishibashi;Masahiko Hashimoto;Kiyohito Yosida;H. Kato;Y. Naritaka;Y. Okada;K. Ogawa
为探讨大肠癌肝转移与Fas配体（Fas L）表达的关系，对67例大肠癌进行了检测。Fas L表达阳性48例，阴性19例。Fas L阳性病例中14例有肝转移，包括异时转移。然而，在Fas L阴性患者中，仅1例发生肝转移（p = 0.0344）。在伴有静脉侵犯的结直肠癌中，25例Fas L阳性病例中有13例出现肝转移，但19例阴性病例中只有1例出现肝转移（p = 0.0003）。在无静脉侵犯的病例中，Fas L阴性病例未观察到肝转移。这些结果表明Fas L表达可能是结直肠癌伴静脉浸润肝转移的预测因子。
The expression of Fas ligand (Fas L) was investigated in sixty-seven patients with colorectal cancer for possible correlation with liver metastasis. Fas L expression was positive in 48 and negative in 19 cases. In Fas L-positive cases, 14 patients had liver metastasis including metachronous metastasis. However, only one case had liver metastasis in Fas L-negative patients (p = 0.0344). In colorectal cancer with venous invasion, 13 from 25 Fas L-positive cases had liver metastasis but only one in 19 negative cases (p = 0.0003). In the cases without venous invasion, no liver metastasis was observed in Fas L-negative cases. These results suggest that Fas L expression may be a predictive factor for liver metastasis in colorectal cancer with venous invasion.