Correlation between IRGM genetic polymorphisms and Crohn's disease risk: a meta-analysis of case-control studies
Correlation between IRGM genetic polymorphisms and Crohn's disease risk: a meta-analysis of case-control studies
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DOI：
10.4238/2014.december.18.15
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发表时间：
2014-01-01
影响因子：
0.4
通讯作者：
You, J. -H.
中科院分区：
文献类型：
--
作者：
Li, Y.;Feng, S. -T.;You, J. -H.
本荟萃分析旨在评估免疫相关GTPase M （IRGM）基因单核苷酸多态性（snp）与克罗恩病（CD）风险之间的关系。11项病例对照研究纳入了5183名乳糜泻患者和5571名健康对照者。评估了IRGM基因中三个常见的snp （rs13361189 C>T、rs10065172 C>T和rs4958847 A>G）。我们发现IRGM rs13361189多态性与CD风险增加显著相关[C等位基因vs T等位基因]：优势比(OR) = 1.30, 95%可信区间(CI) = 1.05-1.61, P = 0.017；CC + CT vs TT: OR = 1.32, 95% CI = 1.06 ~ 1.64, P = 0.013]。然而，我们观察到IRGM基因rs10065172和rs4958847多态性与CD易感性之间没有相关性（均P < 0.05）。种族亚组分析显示，IRGM基因多态性与高加索人群中CD风险增加之间存在显著相关性（C等位基因vs T等位基因：OR = 1.22, 95% CI = 1.07-1.40, P = 0.004; CC + CT vs TT: OR = 1.22, 95% CI = 1.05-1.41, P = 0.009），但在亚洲人群中没有相关性（P均为0.05）。meta回归分析也证实种族差异可能是异质性的重要来源（P = 0.003）。我们的meta分析结果表明，IRGM rs13361189多态性与CD易感性有关。因此，IRGM rs13361189多态性有望作为CD早期诊断的生物标志物。然而，IRGM rs10065172和rs4958847多态性可能不是CD风险的主要决定因素。
This meta-analysis was performed to evaluate the relationships between single-nucleotide polymorphisms (SNPs) in the immunity-related GTPase M (IRGM) gene and the risk of Crohn's disease (CD). Eleven case-control studies were included, for a total of 5183 CD patients and 5571 healthy controls. Three common SNPs (rs13361189 C>T, rs10065172 C>T, and rs4958847 A>G) in the IRGM gene were assessed. We found that the IRGM rs13361189 polymorphism was significantly associated with an increased risk of CD [C allele vs T allele: odds ratio (OR) = 1.30, 95% confidence interval (CI) = 1.05-1.61, P = 0.017; CC + CT vs TT: OR = 1.32, 95% CI = 1.06-1.64, P = 0.013]. However, we observed no correlation between the rs10065172 and rs4958847 polymorphisms in the IRGM gene with susceptibility to CD (all P > 0.05). Subgroup analysis by ethnicity revealed significant associations between IRGM genetic polymorphisms and an increased risk of CD among Caucasian populations (C allele vs T allele: OR = 1.22, 95% CI = 1.07-1.40, P = 0.004; CC + CT vs TT: OR = 1.22, 95% CI = 1.05-1.41, P = 0.009), but not among Asian populations (all P > 0.05). Meta-regression analysis also confirmed that ethnic differences may be an important source of heterogeneity (P = 0.003). Our meta-analysis results indicate that the IRGM rs13361189 polymorphism contributes to the susceptibility to CD. Thus, the IRGM rs13361189 polymorphism is promising as a biomarker for early diagnosis of CD. However, the IRGM rs10065172 and rs4958847 polymorphisms may not be the major determinants of CD risk.