The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity
The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity
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DOI：
10.1242/jcs.02505
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发表时间：
2005-07-15
影响因子：
4
通讯作者：
Nishida, E
中科院分区：
文献类型：
--
作者：
Ebisuya, M;Kondoh, K;Nishida, E
ERK MAP激酶信号在细胞增殖、分化、迁移和存活等多种细胞功能中起着关键作用。关于这一信号传导的核心问题之一是如何激活相同的蛋白激酶，ERK，引起不同的细胞结果。最近的进展表明，ERK活性的持续时间、强度和亚细胞区隔的差异会产生调节细胞命运决定的信号输出的变化。此外，一些分子已被确定为ERK活性的空间、时间或强度控制调节剂。因此，各种细胞外刺激的信号可以被这些调节因子调节，从而产生ERK活性的定性和定量差异，然后细胞将其解释为适当反应的决定因素。
ERK MAP kinase signaling plays a pivotal role in diverse cellular functions, including cell proliferation, differentiation, migration and survival. One of the central questions concerning this signaling is how activation of the same protein kinase, ERK, elicits distinct cellular outcomes. Recent progress has demonstrated that differences in the duration, magnitude and subcellular compartmentalization of ERK activity generate variations in signaling output that regulate cell fate decisions. Furthermore, several molecules have been identified as spatial, temporal or strength-controlling regulators of ERK activity. Signaling by various extracellular stimuli thus could be modulated by these regulators to give qualitative and quantitative differences in ERK activity, which are then interpreted by the cells as determinants for appropriate responses.