A short echo proton magnetic resonance spectroscopy study of the left mesial-temporal lobe in first-onset schizophrenic patients
A short echo proton magnetic resonance spectroscopy study of the left mesial-temporal lobe in first-onset schizophrenic patients
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DOI：
10.1016/s0006-3223(99)00007-4
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发表时间：
1999-06-01
影响因子：
10.6
通讯作者：
Neufeld, RWJ
中科院分区：
文献类型：
--
作者：
Bartha, R;Al-Semaan, YM;Neufeld, RWJ
背景：过去对精神分裂症患者颞叶的H-1磁共振波谱（MRS）研究表明，n -乙酰天冬氨酸（NAA）水平降低，表明该区域的神经元密度降低。然而，测量到的体积很大，而且主要来自白质。方法：采用短回声H-1 MRS测量II例首发精神分裂症患者和II例年龄、性别、利手性、受教育程度和父母受教育程度相当的健康对照者左内侧颞叶6cm(3)体积内NAA和其他代谢物（即谷氨酸和谷氨酰胺）的水平。光谱在没有操作员交互的情况下使用我们实验室开发的自动化软件进行定量。代谢物水平与所研究的每个体积的内部水浓度归一化。还获得图像以确定颞叶灰质和白质体积。结果：首发精神分裂症患者与对照组之间的NAA或其他代谢物水平或灰质和白质体积无显著差异。结论：由于研究的体积与以前的研究相比较小，并且主要包含灰质，因此该结果表明相应的NAA减少可能仅限于白质区域。(C) 1999年生物精神病学学会。
Background: Past H-1 magnetic resonance spectroscopy (MRS) studies of the temporal lobe in schizophrenic patients have shown decreased levels of N-acetylaspartate (NAA) suggesting reduced neuronal density in this region. However, the measured volumes have been large and included contributions from mostly white matter.Methods: Short echo H-1 MRS was used to measure levels of NAA and other metabolites (i.e., glutamate and glutamine) from a 6 cm(3) volume in the left mesial-temporal lobe of II first-episode schizophrenic patients and II healthy control subjects of comparable age, gender, handedness, education, and parental education levels. Spectra were quantified without operator interaction using automated software developed in our laboratory. Metabolite levels were normalized to the internal water concentration of each volume studied. Images were also obtained to determine temporal lobe gray and white matter volumes.Results: No significant differences were found between levels of NAA or other metabolites or gray and white matter volumes, in first-episode schizophrenic patients and comparison subjects.Conclusions: Since the volume studied was small compared to previous studies and contained mostly gray matter, this result suggests consequential NAA decreases may be restricted to regions of white matter. (C) 1999 Society of Biological Psychiatry.