Implementing personalized medicine: development of a cost-effective customized pharmacogenetics genotyping array.
Implementing personalized medicine: development of a cost-effective customized pharmacogenetics genotyping array.
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DOI：
10.1038/clpt.2012.125
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发表时间：
2012-10
影响因子：
6.7
通讯作者：
中科院分区：
文献类型：
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尽管有越来越多的证据支持在某些临床情况下实施药物遗传学，但这种方法的采用受到限制。对关键的药物遗传变异进行先发制人和廉价检测的出现，可能会克服采用这种方法的障碍。我们描述了为佛罗里达大学和斯坦福大学的个性化医疗项目设计的定制阵列。我们使用药物基因组学知识库（PharmGKB）的临床注释为该阵列选择了关键变体，我们包括药物代谢和转运基因的变体以及其他药理学上重要的变体。
Although there is increasing evidence to support the implementation of pharmacogenetics in certain clinical scenarios, the adoption of this approach has been limited. The advent of preemptive and inexpensive testing of critical pharmacogenetic variants may overcome barriers to adoption. We describe the design of a customized array built for the personalized-medicine programs of the University of Florida and Stanford University. We selected key variants for the array using the clinical annotations of the Pharmacogenomics Knowledgebase (PharmGKB), and we included variants in drug metabolism and transporter genes along with other pharmacogenetically important variants.
影响因子：
6.7
作者：
通讯作者：
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