Performance of an Influenza Rapid Test in Children in a Primary Healthcare Setting in Nicaragua
Performance of an Influenza Rapid Test in Children in a Primary Healthcare Setting in Nicaragua
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DOI：
10.1371/journal.pone.0007907
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发表时间：
2009-11-19
期刊：
影响因子：
3.7
通讯作者：
Harris, Eva
中科院分区：
文献类型：
--
作者：
Gordon, Aubree;Videa, Elsa;Harris, Eva
背景：流感是全世界主要的公共卫生威胁，但发展中国家快速检测的诊断准确性尚未得到很好的描述。方法/主要发现：为了调查 QuickVue 流感 A+B 检测在发展中国家初级保健机构中的诊断准确性，我们对 2 岁至 2 岁儿童初级保健机构中 QuickVue 流感 A+B 检测与逆转录酶聚合酶链反应 (RT-PCR) 的诊断准确性进行了前瞻性研究。在尼加拉瓜马那瓜生活了 12 年。对于发烧或有发烧、咳嗽和/或喉咙痛病史的儿童，与 RT-PCR 相比，QuickVue 检测的敏感性和特异性分别为 68.5% (95% CI 63.4, 73.3) 和 98.1% (95% CI 96.9, 98.9)。结果发现，与患病第二天或第三天的测试性能相比，出现症状第一天的测试性能较低。结论/意义：我们的研究发现，QuickVue 流感 A+B 测试在发展中国家初级医疗机构环境中的表现与在发达国家环境中的性能一样好。
Background: Influenza is major public health threat worldwide, yet the diagnostic accuracy of rapid tests in developing country settings is not well described.Methodology/Principal Findings: To investigate the diagnostic accuracy of the QuickVue Influenza A+B test in a primary care setting in a developing country, we performed a prospective study of diagnostic accuracy of the QuickVue Influenza A+B test in comparison to reverse transcriptase-polymerase chain reaction (RT-PCR) in a primary healthcare setting in children aged 2 to 12 years in Managua, Nicaragua. The sensitivity and specificity of the QuickVue test compared to RT-PCR were 68.5% (95% CI 63.4, 73.3) and 98.1% (95% CI 96.9, 98.9), respectively, for children with a fever or history of a fever and cough and/or sore throat. Test performance was found to be lower on the first day that symptoms developed in comparison to test performance on days two or three of illness.Conclusions/Significance: Our study found that the QuickVue Influenza A+B test performed as well in a developing country primary healthcare facility setting as in developed country settings.