Outcome of symptomatic congenital cytomegalovirus infection: results of long-term longitudinal follow-up.
Outcome of symptomatic congenital cytomegalovirus infection: results of long-term longitudinal follow-up.
复制标题
DOI：
10.1542/peds.66.5.758
复制
发表时间：
1980-11
期刊：
影响因子：
8
通讯作者：
R. F. Pass;S. Stagno;G. Myers;C. Alford
中科院分区：
文献类型：
--
作者：
R. F. Pass;S. Stagno;G. Myers;C. Alford
34例新生儿时有症状的先天性巨细胞病毒感染患者在一家专门的诊所进行随访，定期进行医学和视觉检查，并进行心理测试和听力测试。所有患者在2周大时都有先天性感染的症状，34名患者中有31名在出生后1个月内从尿液中分离出病毒。最近一次随访的年龄从9个月到14岁不等，平均4岁。10名患者死亡，23名幸存患者接受了充分的后续检查；除两人外，所有人都有中枢神经系统或听力障碍的证据。小头畸形16例(70%)，智力低下14例(61%)，听力损失7例(30%)，神经肌肉障碍8例(35%)，脉络膜视网膜炎或视神经萎缩5例(22%)。有症状的先天性巨细胞病毒感染的儿童患残疾的风险非常高，这将严重损害发育。
Thirty-four patients with congenital cytomegalovirus infection who were symptomatic as newborns were followed in a special clinic providing periodic medical and visual examinations as well as psychometric testing and audiometry. All patients had symptoms of congenital infection by 2 weeks of age, and 31 of 34 had virus isolated from urine within the first month of life. Age at latest follow-up varied from 9 months to 14 years with a mean of about 4 years. Ten patients died and 23 surviving patients had adequate follow-up examinations; all but two had evidence of central nervous system or auditory handicaps. Microcephaly was present in 16 (70%), mental retardation in 14 (61%), hearing loss in seven (30%), neuromuscular disorders in eight (35%), and chorioretinitis or optic atrophy in five (22%). Children with symptomatic congenital cytomegalovirus infection are at very high risk for handicaps that will significantly impair development.