Examining the mechanisms that link β-amyloid and α-synuclein pathologies.
Examining the mechanisms that link β-amyloid and α-synuclein pathologies.
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DOI：
10.1186/alzrt109
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Blurton-Jones M
中科院分区：
文献类型：
--
作者：
Marsh SE;Blurton-Jones M
β-淀粉样蛋白 (Aβ) 和 α-突触核蛋白 (α-syn) 是易于聚集的蛋白质，通常与两种不同的神经退行性疾病相关：阿尔茨海默病 (AD) 和帕金森病。然而，α-syn 最初被发现与 AD 斑块相关，几年后才被发现与帕金森病或路易体形成相关。如今，大部分 AD 患者 (~50%) 被公认为同时表现出显着的 α-syn Lewy 体病理学。不幸的是，这些 AD 路易体变异患者患有额外的症状和加速的病程。基础研究已经开始表明Aβ和α-syn可能协同作用，促进彼此的聚集和积累。虽然这些蛋白质相互作用的确切机制仍不清楚，但越来越多的证据表明，Aβ 可能通过损害蛋白质清除、激活炎症、增强磷酸化或直接促进聚集来驱动 α-syn 病理学。本综述研究了 Aβ 和 α-syn 之间的相互作用，并提出了 Aβ 积累和 α-syn 发病机制之间的潜在机制联系。
β-amyloid (Aβ) and α-synuclein (α-syn) are aggregation-prone proteins typically associated with two distinct neurodegenerative disorders: Alzheimer's disease (AD) and Parkinson's disease. Yet α-syn was first found in association with AD plaques several years before being linked to Parkinson's disease or Lewy body formation. Nowadays, a large subset of AD patients (~50%) is well recognized to co-exhibit significant α-syn Lewy body pathology. Unfortunately, these AD Lewy body variant patients suffer from additional symptoms and an accelerated disease course. Basic research has begun to show that Aβ and α-syn may act synergistically to promote the aggregation and accumulation of each other. While the exact mechanisms by which these proteins interact remain unclear, growing evidence suggests that Aβ may drive α-syn pathology by impairing protein clearance, activating inflammation, enhancing phosphorylation, or directly promoting aggregation. This review examines the interactions between Aβ and α-syn and proposes potential mechanistic links between Aβ accumulation and α-syn pathogenesis.
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影响因子：
2.5
作者：
Fujishiro, Hiroshige;Iseki, Eizo;Sato, Kiyoshi
通讯作者：
Sato, Kiyoshi
影响因子：
9.9
作者：
Ballard, C.;Ziabreva, I.;Aarsland, D.
通讯作者：
Aarsland, D.
影响因子：
4.8
作者：
Inglis, Kelly J.;Chereau, David;Brigham, Elizabeth F.;Chiou, San-San;Schoebel, Susanne;Frigon, Normand L.;Yu, Mei;Caccavello, Russell J.;Nelson, Seth;Motter, Ruth;Wright, Sarah;Chian, David;Santiago, Pamela;Soriano, Ferdie;Ramos, Carla;Powell, Kyle;Goldstein, Jason M.;Babcock, Michael;Yednock, Ted;Bard, Frederique;Basi, Guriqbal S.;Sham, Hing;Chilcote, Tamie J.;McConlogue, Lisa;Griswold-Prenner, Irene;Anderson, John P.
通讯作者：
Anderson, John P.
DOI：
10.1523/jneurosci.0490-10.2010
发表时间：
2010-05-26
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Clinton LK;Blurton-Jones M;Myczek K;Trojanowski JQ;LaFerla FM
通讯作者：
LaFerla FM
影响因子：
21.3
作者：
Fujiwara, H;Hasegawa, M;Iwatsubo, T
通讯作者：
Iwatsubo, T