Caveolin and proteasome in tocotrienol mediated myocardial protection
Caveolin and proteasome in tocotrienol mediated myocardial protection
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DOI：
10.1159/000149807
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发表时间：
2008-01-01
影响因子：
--
通讯作者：
Das, Dipak K.
中科院分区：
文献类型：
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作者：
Das, Manika;Das, Samarjit;Das, Dipak K.
研究了生育三烯醇不同异构体对心肌缺血再灌注损伤的影响。虽然所有的生育三烯醇异构体都有一定程度的心脏保护作用，但从心肌凋亡的结果来看，γ -生育三烯醇的保护作用最强。为了研究生育三烯醇介导的心脏保护机制，我们研究了不同信号成分与小窝蛋白和蛋白酶体活性的相互作用和/或易位。结果表明，MAP激酶与小窝蛋白1/3的差异相互作用与蛋白酶体稳定结合，可能通过改变促生存和抗生存蛋白的可用性，在生育三烯醇介导的心脏保护中发挥了独特的作用。版权所有2008 S. Karger AG，巴塞尔
The effect of different isomers of tocotrienol was tested on myocardial ischemia reperfusion injury. Although all of the tocotrienol isomers offered some degree of cardioprotection, gamma-tocotrienol was the most protective as evident from the result of myocardial apoptosis. To study the mechanism of tocotrienol mediated cardioprotection, we examined the interaction and/or translocation of different signaling components to caveolins and activity of proteasome. The results suggest that differential interaction of MAP kinases with caveolin 1/3 in conjuncture with proteasome stabilization play a unique role in tocotrienol mediated cardioprotection possibly by altering the availability of pro-survival and anti-survival proteins. Copyright (C) 2008 S. Karger AG, Basel.