Expression of APOBEC3G in kidney cells
Expression of APOBEC3G in kidney cells
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DOI：
10.1111/j.1399-0039.2006.00725.x
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Itoh, K.
中科院分区：
文献类型：
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作者：
Komohara, Y.;Suekane, S.;Itoh, K.
载脂蛋白 B mRNA 编辑酶催化多肽样 3G (APOBEC3G) 是 APOBEC 家族的成员，通过胞嘧啶脱氨基作用具有 DNA 突变活性，据报道在宿主防御乙型肝炎病毒和人类免疫缺陷病毒等感染中发挥重要作用。在这里，我们检查了人肾细胞中 APOBEC3G 的表达，以更好地了解其抗感染的生物学作用。 APOBEC3G 在肾系膜细胞中可以通过免疫组织化学方法检测到，在肾上皮肾小管细胞中也可以在一定程度上检测到 APOBEC3G。此外，APOBEC3G 在肾癌组织和细胞系中过度表达。 APOBEC3G 表达受到炎症细胞因子的上调，例如干扰素、白细胞介素 6 和肿瘤坏死因子。这些结果可能为 APOBEC3G 在宿主防御病毒感染和癌症中的作用提供新的见解。
The apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G), a member of the APOBEC family possessing DNA mutator activity through cytosine deamination, is reported to play an important role in host defense against infections such as those of hepatitis B virus and human immunodeficiency virus. Here, we examined the expression of APOBEC3G in human kidney cells to better understand its biological role against infection. APOBEC3G was immunohistochemically detectable in kidney mesangial cells and also to some extent in kidney epithelial tubular cells. In addition, overexpression of APOBEC3G was shown in renal carcinoma tissues and cell lines. APOBEC3G expression was upregulated by inflammatory cytokines, such as interferon, interleukin-6, and tumor necrosis factor. These results may provide new insight into the role of APOBEC3G in host defense against viral infection and cancer.