BMY 7378 is an agonist at 5-HT1A receptors mediating hypotension and renal sympatho-inhibition in anaesthetised cats.
BMY 7378 is an agonist at 5-HT1A receptors mediating hypotension and renal sympatho-inhibition in anaesthetised cats.
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BMY 7378 是 5-HT1A 受体的激动剂，可介导麻醉猫的低血压和肾交感神经抑制。
DOI：
10.1016/0014-2999(91)90373-x
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发表时间：
1991
影响因子：
5
通讯作者：
W. Feniuk
中科院分区：
文献类型：
--
作者：
C. M. Stubbs;H. Connor;W. Feniuk
推定的 5-HT1A 受体拮抗剂 BMY 7378 (3–100 μg·kg−1i.v.) 导致麻醉猫的血压、心率和传出肾神经活动降低。选择性 5-HT1A 受体激动剂 8-羟基-2（二正丙氨基）四氢萘 (8-OH-DPAT 1–10 μg·kg−1i.v.) 也产生类似的效果。 BMY 7378 和 8-OH-DPAT 的交感神经抑制作用（而非可乐定的作用）被非选择性 5-HT1A 受体拮抗剂螺哌隆 (1 mg·kg−1i.v.) 逆转。结论是，BMY 7378 中的交感神经抑制是 5-HT1A 受体的激动剂，介导低血压和肾麻醉猫。
The putative 5-HT1Areceptor antagonist BMY 7378 (3–100 μg · kg−1i.v.) caused reductions in blood pressure, heart rate and efferent renal nerve activity in anaesthetised cats. Similar effects were produced by the selective 5-HT1Areceptor agonist, 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT 1–10 μg · kg−1i.v.). The sympatho-inhibitory effects of BMY 7378 and 8-OH-DPAT, but not those of clonidine were reversed by the non-selective 5-HT1Areceptor antagonist, spipirone (1 mg · kg−1i.v.). It is concluded that sympatho-inhibition inBMY 7378 is an agonist at 5-HT1Areceptors mediating hypotension and renal anaesthetised cats.
DOI：
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发表时间：
1989
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Gleeson,S;Ahlers,ST;Mansbach,RS;Foust,JM;Barrett,JE
通讯作者：
Barrett,JE