Vitamin D status among preterm infants with cholestasis and metabolic bone disease.
Vitamin D status among preterm infants with cholestasis and metabolic bone disease.
复制标题
患有胆汁淤积和代谢性骨病的早产儿的维生素 D 状况。
DOI：
10.1038/s41390-019-0501-x
复制
发表时间：
2019
影响因子：
3.6
通讯作者：
Berkovitz,Gary
中科院分区：
文献类型：
--
作者：
Ukarapong,Supamit;Zegarra,Walter;Navarrete,Cristina;Seeherunvong,Tossaporn;Berkovitz,Gary
BackgroundMetabolic bone disease of prematurity (MBD) is a common problem among preterm infants. Our previous study identified cholestasis as an important risk factor for the development of MBD. We conducted this study to determine the vitamin D status in preterm infants with MBD and cholestasis.MethodsWe retrospectively reviewed medical record of preterm infants evaluated in NICU at Holtz Children’s/Jackson Memorial Hospital between June 2014 and May 2016. Demographic, biochemical data, and vitamin D intake were collected and analyzed.ResultsWe identified 58 preterm infants (median gestational age 25 weeks) with MBD during this period. Twenty five infants also developed cholestasis. Median serum 25-hydroxyvitamin D level at the time of diagnosis of MBD was similar in cholestasis (C), (29.1 ng/ml, IQR 24.4–33.5), and non-cholestasis (NC), (28.7 ng/ml, IQR 22.7–34.6), group (p= 0.41). At the second measurement, average 6 weeks after the first measurement; median serum 25-hydroxyvitamin D level was lower (p= 0.02) in the C group (31.2 ng/ml, IQR 23.0–38.8) than in the NC group (36.5 ng/ml, IQR 28–45). However, the actual percentage of infants with vitamin D deficiency was similar in both the groups.ConclusionMost preterm infants with cholestasis and MBD had normal vitamin D status.
