Molecular analysis of spontaneous somatic mutants
Molecular analysis of spontaneous somatic mutants
复制标题
自发体细胞突变体的分子分析
作者：
K. Adetugbo;C. Milstein;D. Secher
小鼠骨髓瘤细胞系中自发发生的真核结构基因突变为在分子水平上研究动物细胞的体细胞突变提供了机会。对骨髓瘤蛋白和 mRNA 的研究使我们能够表征代表四种不同突变机制的四种突变体。结果可能对抗体多样性的起源有一定影响。
Eukaryotic structural gene mutations occurring spontaneously in a mouse myeloma cell line offer the opportunity to study somatic mutation in animal cells at the molecular level. Studies on the myeloma protein and on mRNA have enabled us to characterise four such mutants representing four different mutation mechanisms. The results may have some bearing on the origin of antibody diversity.