Electrochemically generated N-iodoaminium species as key intermediates for selective methyl sulphonylimination of tertiary amines
Electrochemically generated N-iodoaminium species as key intermediates for selective methyl sulphonylimination of tertiary amines
复制标题
电化学生成的 N-碘胺作为叔胺选择性甲基磺酰亚胺化的关键中间体
DOI：
10.1039/c9cc09869k
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发表时间：
2020-05-07
影响因子：
4.9
通讯作者：
Xia, Wujiong
中科院分区：
文献类型：
--
作者：
Huang, Binbin;Yang, Chao;Xia, Wujiong
本文报道了一种通过磺胺和叔胺之间的电驱动、碘介导的交叉脱氢缩合(CDC)来接近N-磺酰胺的直接协议，该方法具有对胺对N-CH3的独有选择性。机理研究表明，原位生成的N-碘代胺物种是关键的中间体。
Reported herein is a straightforward protocol for approaching N-sulphonylamidines via an electricity-driven, iodine-mediated cross dehydrogenative condensation (CDC) between sulphonamides and tertiary amines, which features exclusive N-CH3 selectivity for the amine partners. Mechanistic studies indicate that an in situ generated N-iodoaminium species serves as the key intermediate.