Preparation of novel polymer assemblies, "lactosome", composed of Poly(L-lactic acid) and poly(sarcosine)
Preparation of novel polymer assemblies, "lactosome", composed of Poly(L-lactic acid) and poly(sarcosine)
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DOI：
10.1246/cl.2007.1220
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发表时间：
2007-10-05
影响因子：
1.6
通讯作者：
Kimura, Shunsaku
中科院分区：
文献类型：
--
作者：
Makino, Akira;Yamahara, Ryo;Kimura, Shunsaku
通过丙交酯和肌氨酸N-羧酸酐的连续聚合，合成了由聚L乳酸(PLLA)和聚肌氨酸(PS)组成的新型两亲性嵌段聚合物。每个嵌段的聚合度由进料中单体/引发剂的比例控制。嵌段聚合物成功地分散在缓冲液中，根据共聚物的疏水/亲水平衡，呈现出不同的胶束、片层和囊泡的形态。分子组装的大小在20~200 nm之间，可作为纳米载体应用于药物传递系统。
Novel amphiphilic block polymers composed Of poly(L-lactic acid) (PLLA) and poly(sarcosine) (PS) were synthesized by successive polymerizations of lactide and sarcosine N-carboxy anhydride (NCA). The degree of polymerization of each block was controlled by the monomer/initiator ratio in feed. The block polymers were successfully dispersed in buffer with taking various morphologies of micelle, lamellar, and vesicle depending on the hydrophobic/hydrophilic balance of the copolymers. The size of the molecular assemblies was in the range from 20 to 200 nm, which may be available for drug delivery system (DDS) as nanocarrier.