Gut Microbiome and Colon Cancer: Role of Bacterial Metabolites and Their Molecular Targets in the Host.
Gut Microbiome and Colon Cancer: Role of Bacterial Metabolites and Their Molecular Targets in the Host.
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DOI：
10.1007/s11888-017-0362-9
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发表时间：
2017-04
影响因子：
--
通讯作者：
Ganapathy V
中科院分区：
文献类型：
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作者：
Bhutia YD;Ogura J;Sivaprakasam S;Ganapathy V
结肠细菌和宿主之间的关系是共生的，但这两个伙伴之间的交流如何发生才刚刚开始在分子水平上被理解。在这里，我们强调了存在于结肠腔中的细菌代谢的特定产物及其在宿主中促进这种通信的分子靶点。结肠上皮细胞和粘膜免疫细胞表达几种细胞表面受体和核受体，这些受体被特定的细菌代谢物激活，影响多种信号通路和许多基因的表达。此外，一些细菌代谢物还具有通过抑制参与维持组蛋白乙酰化和DNA甲基化模式的选择性酶而引起这些细胞中的表观遗传变化的能力。结肠细菌通过与宿主分子靶点相互作用的选择性代谢物与宿主交流。这种化学通讯是结肠上皮细胞和粘膜免疫细胞的广泛生物学和功能的基础，这些细胞在正常生理条件下保护结肠免受炎症和致癌作用。
The relationship between colonic bacteria and the host is symbiotic, but how communication between the two partners occurs is just beginning to be understood at the molecular level. Here, we highlight specific products of bacterial metabolism that are present in the colonic lumen and their molecular targets in the host that facilitate this communication. Colonic epithelial cells and mucosal immune cells express several cell-surface receptors and nuclear receptors that are activated by specific bacterial metabolites, which impact multiple signaling pathways and expression of many genes. In addition, some bacterial metabolites also possess the ability to cause epigenetic changes in these cells via inhibition of selective enzymes involved in the maintenance of histone acetylation and DNA methylation patterns. Colonic bacteria communicate with their host with selective metabolites that interact with host molecular targets. This chemical communication underlies a broad range of the biology and function of colonic epithelial cells and mucosal immune cells, which protect against inflammation and carcinogenesis in the colon under normal physiological conditions.