Programmed death-ligand 1 expression in gastric adenocarcinoma is a poor prognostic factor in a high CD8+ tumor infiltrating lymphocytes group.
Programmed death-ligand 1 expression in gastric adenocarcinoma is a poor prognostic factor in a high CD8+ tumor infiltrating lymphocytes group.
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DOI：
10.18632/oncotarget.12603
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发表时间：
2016-12-06
期刊：
影响因子：
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通讯作者：
Kim BH
中科院分区：
文献类型：
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作者：
Chang H;Jung WY;Kang Y;Lee H;Kim A;Kim HK;Shin BK;Kim BH
胃腺癌是癌症相关死亡的最常见原因之一。在这项研究中，我们使用来自464个胃癌样本的组织芯片对PD-L1、PD-1、CTLA-4和CD8进行了免疫组织化学研究，并评估了它们的表达、临床病理因素和5年总生存率之间的相关性。PD-L1和PD-1的表达与一些不良预后病理因素显著相关，包括高t期、弥漫性Lauren组织学类型和淋巴浸润。相反，CTLA-4的表达与临床预后良好的因素相关。一项完整的病例分析显示，在单变量分析中，高PD-L1和PD-1表达对5年总生存率有不利影响。根据CD8+肿瘤浸润淋巴细胞水平（高和低）将患者分为两组的亚组分析显示，高PD-L1表达仅在高CD8+肿瘤浸润淋巴细胞组中是一个显著的不良预后因素。需要进一步的研究和临床试验来确定这些发现的临床用途。
Gastric adenocarcinoma is one of the most common causes of cancer-related death. In this study, we conducted immunohistochemical studies for PD-L1, PD-1, CTLA-4, and CD8 using tissue microarrays from 464 gastric cancer samples and evaluated the correlations between their expression, clinicopathologic factors, and five-year overall survival. PD-L1 and PD-1 expression was significantly correlated with several adverse prognostic pathologic factors, including higher T-stage, diffuse Lauren histologic type, and lymphatic invasion. Conversely, CTLA-4 expression was correlated with factors of favorable clinical outcomes. A complete case analysis revealed that high PD-L1 and PD-1 expression had an adverse effect on five-year overall survival in univariate analyses. Subgroup analyses wherein patients were divided into two groups according to CD8+ tumor infiltrating lymphocyte levels (high and low) showed that high PD-L1 expression was a significant adverse prognostic factor only in the high CD8+ tumor-infiltrating lymphocytes group. Further research and clinical trials are needed to determine the clinical usefulness of these findings.