Neuroplastic Changes Following Brain Ischemia and their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation.
Neuroplastic Changes Following Brain Ischemia and their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation.
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DOI：
10.3389/fncel.2017.00076
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发表时间：
2017
影响因子：
5.3
通讯作者：
Caleo M
中科院分区：
文献类型：
--
作者：
Alia C;Spalletti C;Lai S;Panarese A;Lamola G;Bertolucci F;Vallone F;Di Garbo A;Chisari C;Micera S;Caleo M
脑缺血性损伤会触发备用区域和通路的实质性重组，这与功能的有限自发恢复有关。更好地了解这种可塑性重塑对于制定更有效的中风康复策略至关重要。在这篇综述文章中，我们讨论了在患者和动物模型中风后网络重组的理解的进展。我们首先集中在啮齿动物的研究，揭示了潜在的机制，在运动皮层梗死后的病灶周围区域和对侧半球的神经元重塑。对电生理数据的分析表明，大脑两半球的功能连接发生了全脑范围的改变，远远超出了梗死区。然后，我们说明了潜在的使用非侵入性脑刺激（NIBS）技术，以促进恢复。最后，我们讨论了基于机器人设备的康复协议，作为一种工具，以促进内源性可塑性和功能恢复。
Ischemic damage to the brain triggers substantial reorganization of spared areas and pathways, which is associated with limited, spontaneous restoration of function. A better understanding of this plastic remodeling is crucial to develop more effective strategies for stroke rehabilitation. In this review article, we discuss advances in the comprehension of post-stroke network reorganization in patients and animal models. We first focus on rodent studies that have shed light on the mechanisms underlying neuronal remodeling in the perilesional area and contralesional hemisphere after motor cortex infarcts. Analysis of electrophysiological data has demonstrated brain-wide alterations in functional connectivity in both hemispheres, well beyond the infarcted area. We then illustrate the potential use of non-invasive brain stimulation (NIBS) techniques to boost recovery. We finally discuss rehabilitative protocols based on robotic devices as a tool to promote endogenous plasticity and functional restoration.